CAS: 616-76-2; 5-Formyl-2-Hydroxybenzoic Acid

上下游产品

hexamethylenetetramine acetic acid salicylic acid 4-hydroxyisophthalic acid 5-[3-(5-acetylamino-2-hydroxy-phenyl)-3-oxo-propenyl]-2-hydroxy-benzoic acid 5-formyl-2-hydroxybenzaldehyde 2,5-dihydroxybenzoic acid. 4-hydroxyisophthalic acid

5-甲基水杨酸置于氧气,Cobalt(II) Diacetate Tetrahydrate,Sodium Hydroxide体系中,用 乙二醇 作为反应溶剂,80.0 °C,101.33 Kpa 条件下,反应 8.0H,以89%的收率获得产物5-甲酰水杨酸
参考文献:Ewg取代的4-甲酚的高效co(oac)2催化需氧氧化,以获取4-羟基苯甲醛
标题:Ewg取代的4-甲酚的高效co(oac)2催化需氧氧化,以获取4-羟基苯甲醛
摘要:我们报告了一种高效的无配体co(oac)2 .4H2O / Naoh / O 2 /乙二醇反应系统,该系统能够对包括2,6-Di-Ewg-,2,3在内的多种底物进行选择性好氧氧化,6-Tri-Ewg-,2-Ewg-和2-Ewg-6-Edg取代的4-甲酚变成相应的4-羟基苯甲醛.基于实验研究和明确定义的对苯醌甲基化物,提出了合理的反应机理.考虑到程序的简便性和产品的重要性,该方法有望成为相关的苄基c(sp 3)-h官能化化学中的一种有利且实用的工具.
DOI:10.1016/j.Tetlet.2013.12.077

专利信息

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4837327-A
优先权日:1987-07-13
标 题 :Process for nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4999429-A
优先权日:1989-01-09
标 题 :Process for the preparation of α,α,β-1-trifluoro-1-olefinic derivatives
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:RU-2186055-C2
优先权日:1995-05-24
标 题 :Method of synthesis of derivatives 3-carboxy-4-hydroxybenzaldehyde, method of synthesis of 4-hydroxybenzaldehyde, methods of synthesis of vanillin and ethylvanillin