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CAS号501-36-0 白藜芦醇

📜白藜芦醇 反应 5.5H,反应生成 顺式白藜芦醇
参考文献:白藜芦醇光致异构化的活化能
标题:白藜芦醇光致异构化的活化能
摘要:已知反式二苯乙烯的异构化是由光诱导的.这两种异构体具有不同的吸收,荧光激发和发射光谱.白藜芦醇,3,4',5-三羟基芪,是芪家族的一员.由于其生物医学特性,科学界对白藜芦醇的兴趣在过去几年中增加了.尽管人们越来越相信反式白藜芦醇是无毒的,但对顺式白藜芦醇的药理学知之甚少.正是由于这个原因,人们对了解反式-顺式转换的能量学有相当大的兴趣.与反式相比,顺式白藜芦醇的特点是荧光量子产率大-白藜芦醇.在本文中,我们详细分析了不同时间段内反式白藜芦醇在 260 Nm 激发下引起的光谱变化.在 Ph 4,20,25,30,35,40,45 和 50 oc 下,通过紫外可见吸收和稳态荧光光谱监测光谱变化.连续 260 Nm 激发导致白藜芦醇的吸收和荧光激发光谱发生蓝移,其荧光发射发生 14 Nm 蓝移.光异构化产率报告为 260 Nm 激发时间的函数.330 分钟的连续激发导致~60% 的异构化产率.在连续
DOI:10.1007/s10895-011-0886-3

专利信息

专利号:US-2008194417-A1
优先权日:2005-03-09
标 题:Method for Measuring and Comparing the Activity of Biologically Active Compounds
发明人：BARELLA LUCA; MULLER PATRICK Y; NETSCHER THOMAS; STOECKLIN ELISABETH
权利人:BARELLA LUCA; MULLER PATRICK Y; NETSCHER THOMAS; STOECKLIN ELISABETH
摘要:Biologically active compounds (e.g. from the groups of pharmaceutical drugs, cofactors, hormones, vitamins or phytochemicals) often consist of two or more stereoisomers (enantiomers or diastereoisomers) which may differ in their pharmacodynamic/kinetic, toxicological and biological properties. These differences are so far difficult to detect. A well known example for a biologically active compound and its counterpart is vitamin E which is predominantly administered as two different ‘forms’, one derived from natural sources (mainly soybeans), and one from production by chemical total-synthesis. While vitamin E from natural sources occurs as a single stereoisomer (RRR-α-tocopherol), so-called synthetic vitamin E (all-rac-α-tocopherol) is an equimolar mixture of eight stereoisomers. The present invention is directed to a method for calculating the biological activity of a biologically active compound (e.g. RRR-α-tocopherol) and a counterpart thereof (e.g. all-rac-α-tocopherol), comprising the steps of: culturing a plurality of cells in a culture medium and treating the cells with different concentrations of either said compound or said counterpart thereof; or treating a plurality of animals or plants with different concentrations of either said compound or said counterpart; preparing samples from the treated cells or animals or plants containing a pool of target nucleic acids comprising RNA transcripts; detecting the expression of genes in said cells by measuring the amount of transcripts of said genes to obtain a target expression pattern by hybridizing said pool of target nucleic acids to an array of nucleic acid probes immobilized on a surface, wherein said array comprising at least 10 different nucleic acids, some of which comprise control probes, and wherein each different nucleic acid is localized in a known location of said surface; quantifying the hybridization of said nucleic acids to said array by comparing binding of matched and control probes; calculating the biological activity of the compound and its counterpart therefrom.

专利号:US-7309591-B2
优先权日:2002-01-24
标 题:Method for the production of resveratrol in cell cultures
发明人：BRU MARTINEZ ROQUE; PEDRENO GARCIA MARIA DEL LOS A
权利人:UNIV ALICANTE
摘要:The invention relates to a method for the production of resveratrol in cell cultures. The inventive method consists in: incubating a culture of cells which produce resveratrol naturally, in suspension, in the presence of randomly-methylated β-cyclodextrin (RMBCD) with a degree of substitution of between 11 and 13 under conditions that allow resveratrol synthesis and the excretion of same into the culture medium; and, if desired, isolating the resveratrol produced from said culture medium. The resveratrol can be used in the production of pharmaceutical or nutraceutical products.

专利号:WO-2025212579-A1
优先权日:2024-04-01
标题:Methods and compositions for inhibition of tyrosine and phenylalanine-mediated dna damage and repair
发明人：MATHEW SAJISH
权利人:UNIV SOUTH CAROLINA
摘要:Disclosed are compounds, compositions, and methods for inhibiting tyrosine-mediated DNA repair in a neuroprotective manner and/or activating transcription and/or protein synthesis. Compositions include a resveratrol, such as cis-resveratrol, or a compound of Formula I or Formula II. Compounds of Formula I and Formula II have the following structures where the variables, e.g., Y1, Y2, Y3, R1, R2, R3 the A-ring, and W are defined herein. Said compositions may be utilized in treating aging and age-associated neurocognitive and metabolic disorders including various types of cancer. In particular, compositions disclosed herein are neuroprotective against tyrosine/phenylalanine or their metabolites-mediated neurodegeneration and neurocognitive disorders.

专利号:CN-114107080-A
优先权日:2021-11-22
标 题:A kind of engineering bacteria, construction and application of microbial synthesis of resveratrol using glucose as substrate

专利号:US-11718576-B2
优先权日:2014-02-06
标题 :Compositions and methods comprising resveratrol
发明人：CECCOLI JOSEPH D; COSTELLO BRIAN R; INGRASSIA MICHAEL L; JUDD CHRISTOPHER M; SZCZEPANIK MACIEJ BERNARD
权利人:BIOCOGENT LLC
摘要:The present technology relates to synthesis of resveratrol compositions, in particular to methods of synthesizing resveratrol salicylates such as those formed through the activation of resveratrol and salicylic acid, and cosmetic and pharmaceutical compositions comprising the same.

专利号:US-2025241878-A1
优先权日:2022-01-24
标题:Tyrosine and resveratrol derivatives as novel modulators of cellular serine adp-ribosylation
发明人：MATHEW SAJISH
权利人:UNIV SOUTH CAROLINA
摘要:Methods and compositions are described herein for modulating protein synthesis, especially monosome translation and DNA damage response, especially short-patch base excision repair (SP-BER), NHEJ and HR for treating a disorder. Compositions include a therapeutically effective amount of a tyrosine or a resveratrol derivative.