CAS: 5835-26-7; Isopimaric Acid

该化合物是一种自然形成的有机化合物,被归类为二苯酸,主要来自某些细松树树的树脂,特别是皮纳塞氏家族的树脂.异硫酸的化学结构具有双环框架的特点,有助于其独特的特性.其特点是乙醇和丙酮等有机溶剂的熔点和溶性相对较高,但水溶性较少.异硫酸展示生物活动,包括潜在的抗微生物和抗炎特性,使其对药理研究感兴趣.此外,它可以产生多种化学反应,例如可以用于合成有机化学的酯化和氧化作用.在天然树脂中的存在也使其与植物化学和生态研究有关.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

[ECHA物质

上下游产品

CAS号483-87-4 1,7-二甲基菲 | CAS号514-10-3 松香酸 | CAS号2471-58-1 8a-Pod°Carpane-... | CAS号1740-37-0 8a-Pod°Carpan-1... | CAS号1686-62-0 (1R)-7α-Ethenyl... | CAS号1740-36-9 methyl 9-hydrox...

合成工艺路线路线简述

    📜Isopimaric Acid Chloride,聚甘氨酸置于potassium Carbonate,Potassium Hydroxide体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 72.0H,以31%的收率获得产物
    参考文献:高级萜类化合物的合成转化.39.*异海松酸衍生物的合成及镇痛活性
    标题:高级萜类化合物的合成转化.39.*异海松酸衍生物的合成及镇痛活性
    摘要:制备了异海松酸羧酸的新衍生物.在内脏痛和热痛模型中研究了它们的镇痛活性.异海松酸酰胺与氨基乙醇和 (2 R)-(羟甲基)吡咯烷组在乙酸诱导的扭体(5 和 25 Mg/kg 剂量)和热板试验(25 Mg/kg 剂量)中表现出统计学上显着的镇痛活性.与双氯芬酸钠(10 Mg/kg 剂量)相当.新药剂的特点是体内毒性低(ld 50 > 1250 Mg/kg).对最活跃的化合物与跨膜 G 蛋白结合大麻素受体 Cb 2的可能相互作用进行了分子建模.
    DOI:10.1007/s10600-021-03391-1

    海关参考信息

    专利信息


    专利号:EP-3625352-B1
    优先权日:2017-05-19
    标题 :Method for the fermentative de novo synthesis of resin acids
    发明人：JACH GUIDO; SCHULLEHNER KATRIN; WELTERS PETER
    权利人:JOWAT SE

    专利号:US-4540511-A
    优先权日:1984-02-15
    标题:Defoamer and processing aid for wet process phosphoric acid
    发明人：MCCAFFREY EUGENE F; DIETERMAN ALFRED J; KNAZKO LUBA
    权利人:NAT DISTILLERS CHEM CORP
    摘要:A defoamer composition comprising a mixture of defoaming effective amounts of monocarboxylic acid having from 12 to 26 carbon atoms, a monoalkanolamide, and an alcohol selected from the group consisting of primary linear aliphatic alcohols ranging from C 4 to C 20 , primary branch aliphatic alcohols ranging from C 4 to C 20 , and secondary alcohols ranging from C 6 to C 12 ; and a method of inhibiting foaming in a phosphate rock and sulfuric acid medium employed in the synthesis of phosphoric acid by the 'wet process' manufacture of phosphoric acid which comprises adding to the reaction medium an effective amount of the above described defoamer composition.

    专利号:CN-103224616-A
    优先权日:2012-01-26
    标 题:Synthesis of abietic acid-based macromonomers for polyester resin processes

    专利号:CN-103468145-B
    优先权日:2013-09-04
    标题 :A microwave-assisted synthesis method of allyl rosin resinate

    专利号:CN-103468145-A
    优先权日:2013-09-04
    标题:A microwave-assisted synthesis method of allyl rosin resinate

    专利号:CN-103224616-B
    优先权日:2012-01-26
    标 题:Synthesis for the macromonomer based on rosin acid of polyester resin method

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Smith E, Williamson E, Zloh M, Gibbons S. Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus. Phytother Res. 2005 Jun;19(6):538-42. doi: 10.1002/ptr.1711. 23(6):545-555. doi: 10.1080/10286020.2020.1810668. Epub 2020 Aug 28.
    9:24. doi: 10.1186/s13036-015-0022-z.
    4: Salari S, Silverå Ejneby M, Brask J, Elinder F. Isopimaric acid - a multi- targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line. Acta Physiol (Oxf). 2018 Jan;222(1). doi: 10.1111/apha.12895. Epub 2017 Jun 9. 7(11):890-901. doi: 10.1002/open.201800205.

    合成参考文献


    参考文献:10.1515/znc-2005-9-1009
    摘要:Rubio J, Calderón JS, Flores A, Castroa C, Céspedes CL. Trypanocidal activity of oleoresin and terpenoids isolated from Pinus oocarpa. Z Naturforsch C J Biosci. 2005 Sep;60(9-10):711–6. doi: 10.1515/znc-2005-9-1009.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知