3-羟基丙酸叔丁酯置于四溴化碳,三苯基膦体系中,用 乙腈 作为反应溶剂,化学反应生成 3-溴丙酸叔丁酯 参考文献: Pyrrolidine Compounds Which Modulate The Cb2 Receptor[fr] Composés Pyrrolidines Qui Modulent Le Récepteur Cb2 标题: Pyrrolidine Compounds Which Modulate The Cb2 Receptor[fr] Composés Pyrrolidines Qui Modulent Le Récepteur Cb2
专利号:US-2025091989-A1 优先权日:2023-09-19 标 题 :Small molecule protein synthesis modulators 发明人:GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE 权利人:INTERDICT BIO INC 摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.
专利号:US-2012259073-A1 优先权日:2004-04-13 标 题 :Methods for the synthesis of modular poly(phenyleneethynylenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials
专利号:US-2009203867-A1 优先权日:2004-04-13 标 题 :Methods for the synthesis of modular poly(phenyleneethynylenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials
专利号:US-6586615-B1 优先权日:2001-01-10 标题:α-aminoboronic acids prepared by novel synthetic methods 发明人:KETTNER CHARLES A; JAGANNATHAN SHARADA; FORSYTH TIMOTHY PATRICK 权利人:BRISTOL MYERS SQUIBB CO 摘要:The present invention relates to a novel class of alpha-aminoboronic acids of Formula (V),which are useful as intermediates in synthetic processes for inhibitors of the serine proteases, leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin. More specifically, the alpha-aminoboronic acids are useful as intermediates for the synthesis of Hepatitis C Virus (HCV) protease inhibitors. This invention also generally relates to novel methods for the preparation of alpha-aminoboronic acids.
专利号:US-2006054866-A1 优先权日:2004-04-13 标 题 :Methods for the synthesis of modular poly(phenyleneethynlenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials
专利号:EP-1740655-A1 优先权日:2004-04-13 标题 :Methods for the synthesis of modular poly(phenyleneethynylenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials