专利号:US-5139940-A 优先权日:1989-10-26 标题 :Activation compounds and methods of synthesis of activation compounds 发明人:ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W 权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W 摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.
专利号:US-2021284618-A1 优先权日:2016-08-12 标 题 :Furanochalcones as inhibitors of cyp1a1, cyp1a2 and cyp1b1 for cancer chemoprevention 发明人:BHARATE SANDIP BIBISHAN; SHARMA RAJNI; JOSHI PRASHANT; VISHWAKARMA RAM; CHAUDHURI BHABATOSH 权利人:COUNCIL SCIENT IND RES; DE MONTFORT UNIV 摘要:The present invention relates to the furanochalcone class of compounds of general formula A. The present invention particularly relates to the synthesis of furanochalcones and their CYP1A1, CYP1A2 and CYP1B1 inhibitory activity. In addition, the invention relates to the prevention or treatment of cancer caused by polyaromatic hydrocarbons (PAHs), 4-nitroquinoline-1-oxide, and N-nitroso-N-methylurea, heterocyclic amines, estrogen and 17β-estradiol, resulting from the inhibition of CYP1A1, CYP1A2 and CYP1B1 enzymes.
专利号:US-4230624-A 优先权日:1977-09-02 标 题 :Process for the synthesis of derivatives of the benzofuran, chromene and isochromene type 发明人:LE CORRE MAURICE; HERCOUET ALAIN; BEGASSE BEATRICE 权利人:ANVAR 摘要:The invention relates to a process for the production of therapeutic compounds of the benzofuran, chromene and isochromene type of the general formula; in which formula, R1 and R3=H, lower alkyl, aralkyl or cycloalkyl R2=H or an organic radical and when D= R1 and R3 may represent an organic radical. The process comprising the cyclization in the liquid phase and in the presence of a base a compound of the formula; in which formula; R'=an alkyl, aryl or aralkyl radical and X-=an anion.
专利号:EP-0497921-B1 优先权日:1989-10-26 标 题:Method for inhibiting enzymatic synthesis of nucleic acids using isopsoralens 发明人:ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W; HEARST JOHN E 权利人:ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W; HEARST JOHN E 摘要:The invention relates to a device, comprising means for providing electromagnetic radiation (101-106; 201-206; 301-308); means for supporting a sample (109;315) in a fixed relationship with said radiation providing means during irradiation; a housing (100;200;300) for containing said radiation providing means; and means for maintaining the temperature of said sample within a desired temperature range during said irradiation comprising a chamber (107;207;309) positioned interior to said housing and in a fixed relationship to said radiation providing means.
专利号:US-6962906-B2 优先权日:2000-03-14 标题 :Oligonucleotide analogues, methods of synthesis and methods of use 发明人:EFIMOV VLADIMIR; FERNANDEZ JOSEPH; ARCHDEACON DOROTHY; ARCHDEACON JOHN; CHAKHMAKHCHEVA OKSANA; BURYAKOVA ALLA; CHOOB MIKHAIL; HONDORP KYLE 权利人:ACTIVE MOTIF 摘要:The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids (HypNA), and serine peptide nucleic acids (SerNA). The invention includes monomers, homodimers, heterodimers, homopolymers and heteropolymers of these and other oligonucleotide analogues. The present invention includes methods of using these oligonucleotide analogues in the detection and separating of nucleic acid molecules, including uses that include the utilization of oligonucleotide analogues on a solid support. The present invention also includes methods for purifying or separating nucleic acids, such as mRNA molecules, by hybridization with the oligonucleotides of the present invention. The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.
专利号:WO-2021038306-A1 优先权日:2019-08-28 标 题 :Selenophenochromene phosphonic acids, preparation and use as antiproliferative agents 发明人:ARSENJANS PAVELS; DOMRACEVA ILONA; PAEGLE EDGARS 权利人:LATVIAN INST ORGANIC SYNTHESIS 摘要:The present invention relates to a novel selenophenochromene phosphonic acids as antiproliferative agents, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment or prevention of various diseases and disorders by administration of such substances.
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