CAS: 458566-84-2; 4,4-Difluorocyclohexanamine
该化合物是一种有机化合物,其特征是四点环上存在两个附于环的氟原子,以及一个有矿功能的组,该化合物通常具有氟化合物和氨的特性,例如由于矿物质组而增加的极度和氢联结潜力.氟原子的存在可增强化合物的稳定性和影响其再活动,使其在各种化学应用中,包括药物和农用化学品中引起兴趣.六氯环己烷结构有助于其顺质灵活性,这可能影响其与生物目标的相互作用.此外,4,4-二氟环己胺可能在不同溶剂中表现出独特的溶解性特征,受到氟化合物的子成分的影响.安全和处理考虑至关重要,因为潜在的毒性和环境影响,许多氟化合物都具有此种特性.
相似化合物
675112-70-6 675112-67-1 810675-56-0物理性质
上下游产品
CAS号675112-67-1 N-B°C-4,4-二氟环已胺 | CAS号179321-49-4 4-N-B°C-氨基环己酮合成工艺路线路线简述
📜4,4-二氟环己甲酸置于4-二甲氨基吡啶,三甲基氯硅烷,Iron(Iii)-Acetylacetonate,1,2-双(二苯基膦基)苯,氢碘酸,N,N'-二异丙基碳二亚胺,锌体系中,用 N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 17.0H,反应生成 4,4-二氟环己基胺
参考文献:脱羧胺化:二氮丙啶作为单亲电和双亲电氮转移试剂
标题:脱羧胺化:二氮丙啶作为单亲电和双亲电氮转移试剂
摘要:含氮小分子在医学中无处不在,需要继续寻找改进的 Cn 键形成方法.亲电胺化通常需要不同的试剂工具包,其选择取决于待胺化底物的特定结构和功能.此外,这些试剂中的许多都难以处理,会发生不需要的副反应,并且只能在狭窄的范围内发挥作用.在这里,我们报告了使用 Diazirines 作为简单和复杂的氧化还原活性酯脱羧胺化的实用试剂.由此产生的二氮丙啶很容易在一个步骤中多样化为胺,肼和含氮杂环.该反应也已应用于全氟化二氮嗪的氟相合成.
DOI:10.1021/jacs.0C09403
专利信息
专利号:US-9833457-B2
优先权日:2008-01-25
标题:Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
发明人：MJALLI ADNAN M M; GADDAM BAPU; POLISETTI DHARMA RAO; KOSTURA MATTHEW J; GUZEL MUSTAFA
权利人:VTV THERAPEUTICS LLC
摘要:The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to psoriatic arthritis.
专利号:WO-2023081730-A1
优先权日:2021-11-03
标 题:4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer
发明人：ELZEIN ELFATIH; LIU JIWEN
权利人:TEON THERAPEUTICS INC
摘要:The present invention relates to 82 specific 4-hydroxy-2-oxo-1,2- dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid CB2 receptor modulators for the treatment of cancer, e.g. to 6-(4- fluorophenyl)-4-hydroxy-1-(2-(4-methylpiperazin-1-yl)ethyl)-2-oxo-N- (spiro[2.3]hexan-5-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide (example 1, compound 1) The present description discloses the synthesis and characterisation of the 82 claimed compounds as well as biological assays thereof.
专利号:MX-2010007768-A
优先权日:2008-01-25
标题 :TRICICLIC COMPOUNDS AS MODULATORS OF THE SYNTHESIS OF THE ALFA TUMOR NECROSIS FACTOR AND AS INHIBITORS OF PHOSPHODIESTERASE 4.
专利号:WO-2009094528-A1
优先权日:2008-01-25
标 题:TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS
专利号:US-2012172381-A1
优先权日:2008-01-25
标题 :Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors
专利号:US-2018071297-A1
优先权日:2008-01-25
标题 :Tricyclic compounds as modulators of tnf-alpha synthesis and as pde4 inhibitors
