CAS: 4017-56-5; Ethyl 2-Oxocyclooctanecarboxylate

该化合物是一种循环酯,可应用于有机合成和制药中间体,由八人组成的环形结构和活性碳基组组成,成为制造复杂分子的多功能建筑块,特别是在循环和环扩张反应中.酯功能可提高有机溶剂的溶性,便利合成工作流程的处理.该化合物因其在标准条件下的稳定性及其参与核脑生物学添加,凝聚和其他变异的能力而受到重视.其平衡的再活性特征使其适合于需要受控氯酮再反应的精细化学生产和研究应用.建议在惰性条件下适当储存以保持纯度.

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5452-73-3 274255-51-5 1360544-81-5

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CAS号502-49-8 环辛酮 | CAS号105-58-8 碳酸二乙酯 | CAS号623-73-4 重氮乙酸乙酯 | CAS号502-42-1 环庚酮 | CAS号95-92-1 草酸二乙酯 | CAS号502-49-8 环辛酮 | CAS号3002-04-8 Spiro[4.7]dodec... | CAS号13152-02-8 ethylcyclo°Ctane | CAS号13347-96-1 ethyl 2-oxo-1-(... | CAS号10363-27-6 2-methylcyclo°C... | CAS号89745-61-9 ethyl 2-sulfany... | CAS号95338-31-1 12-methyl-oxacy... | CAS号4728-92-1 spiro[5.7]tride... | CAS号38931-77-0 2-prop-2-enylcy... | CAS号38931-65-6 ethyl 1-methyl-...

合成工艺路线路线简述

    📜环辛酮,碳酸二乙酯置于potassium Hydride体系中,用 Paraffin,苯 作为反应溶剂,化学反应 0.5H,以97%的收率获得产物2-氧-1-环辛烷羧酸
    参考文献:Expedient Synthesis Of Unsaturated Amide Alkaloids From Piper Spp: Exploring The Scope Of Recent Methodology
    标题:Expedient Synthesis Of Unsaturated Amide Alkaloids From Piper Spp: Exploring The Scope Of Recent Methodology
    摘要:Sakai芳基醛-环酮aldol-Grob断裂序列被扩展到肉桂醛和环己酮,并将产物改造为吡啶碱类似物.研究了涉及肉桂醛的反应中取代基的影响.当环辛酮或环丁酮替代环己酮或环戊酮时,苯甲醛无法进行aldol-断裂序列,对此失败的原因进行了研究.对吡哆醛-环丁酮aldol-断裂产物进行了四碳wittig同系化,这是通往碱类如retrofractamide A的假设路线,但该方法并不可行.相反,利用lu和trost最近披露的炔化学,对易得的吡哆醛-环戊酮产物进行了三碳同系化,以极高的总产率制备了这些碱类.炔异构化还被用于高效合成辣椒碱和几种其他非芳香2E,4E-二烯酸piper酰胺类碱类.关键词:Piper,酰胺,碱类,杀虫剂,Aldol,断裂,肉桂醛,炔,氧化还原,异构化.
    DOI:10.1139/v96-046

    海关参考信息

    专利信息


    专利号:US-8772301-B2
    优先权日:2009-12-18
    标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
    发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
    权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
    摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

    专利号:US-2009137557-A1
    优先权日:2005-11-22
    标题 :Calcilytic Compounds
    发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
    权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
    摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

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    主要参考文献

    参考标题:Synthesis Of [B]-Condensed Alkyl 3-Hydroxythiophene-2-Carboxylates
    作者:R. Donoso,P. Jordán De Urríes,J. Lissavetzky
    摘要:A Simple Modification Of The Fiesselmann Procedure For The Synthesis Of Bicyclic Alkyl 3-Hydroxythiophene-2-Carboxylates Allow Higher Yields In Only Two Steps.

    合成参考文献


    摘要:Sartori, G.; Maggi, R., Science of Synthesis, (2008) 32, 761.
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