CAS: 37924-85-9; 3-(Bromomethyl)Benzo[d]Isoxazole

相似化合物

4825-75-6 57148-67-1 66033-69-0

上下游产品

CAS号4825-75-6 3-甲基苯并[d]异恶唑 | CAS号37924-67-7 2-(苯并[d]异恶唑-3-基... | CAS号2491-36-3 2-溴-2'-羟基苯乙酮 | CAS号21895-22-7 6-(1-aminoethyl... | CAS号118-93-4 邻羟基苯乙酮 | CAS号181144-26-3 3-羟甲基苯并[D]异恶唑 | CAS号73101-64-1 1,2-苯并异噁唑-3-甲磺酸钠盐 | CAS号88137-14-8 1,2-benzoxazol-... | CAS号84395-93-7 苯并[d]异恶唑-3-甲醛 | CAS号50471-17-5 1,2-Benzisoxazo... | CAS号37924-90-6 1,2-Benzisoxazo...

📜4-Hydroxycoumarin置于硫酸,盐酸羟胺,溴,溶剂黄146,Sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应 26.5H,反应生成3-溴甲基-1,2-苯并异噁唑
参考文献:一种苯并异噁唑类杂环化合物及其制备方法和应用
标题:一种苯并异噁唑类杂环化合物及其制备方法和应用
摘要:本发明涉及一种苯并异噁唑类杂环化合物及其制备方法和应用,其结构式包括式(I),(II),(III),具体提供了该化合物的具体制备方法.该类衍生物具有较好的抗惊厥活性,可以作为抗癫痫药物.

专利信息

专利号:US-7745471-B2
优先权日:2004-06-18
标题:Derivatives of 1,2-benzisoxazole-3-methane sulfonic acid as novel intermediates for the synthesis of zonisamide
发明人：NADDAKA VLADIMIR; KLOPFER EYAL; SAEED SHADY; ARAD ODED; KASPI JOSEPH
权利人:CHEMAGIS LTD
摘要:Derivatives of 1,2-benzisoxazole-3-methanesulfonic acid, which are non-hygroscopic and non-hydrated and their use as intermediates from the preparation of zonisamide are disclosed. Further disclosed are processes of preparing zonisamide from these 1,2-benzisoxazole-3-methanesulfonic acid derivatives, processes of preparing exemplary 1,2-benzisoxazole-3-methanesulfonic acid derivatives and crystalline forms of exemplary 2-benzisoxazole-3-methanesulfonic acid derivatives. A novel process of preparing zonisamide is also disclosed.

专利号:US-2006009644-A1
优先权日:2004-06-18
标 题:Novel crystalline forms of sodium 1,2-benzisoxazole-3-methanesulfonate, processes of preparing same and use thereof in the synthesis of zonisamide
发明人：NADDAKA VLADIMIR; ADIN ITAI; KLOPFER EYAL; ARAD ODED; KASPI JOSEPH
权利人:NADDAKA VLADIMIR; ADIN ITAI; KLOPFER EYAL; ARAD ODED; KASPI JOSEPH
摘要:Disclosed is a process of preparing 1,2-benzisoxazole-3-methanesulfonamide (zonisamide). Also disclosed is a method of dehydrating sodium 1,2-benzisoxazole-3-methanesulfonate, a compound useful in the preparation of 1,2-bisoxazole-3-methanesulfonamide (zonisamide) as well as new crystalline forms of sodium 1,2-benzisoxazole-3-methanesulfonate.

专利号:US-2006014814-A1
优先权日:2004-06-18
标 题:Derivatives of 1,2-benzisoxazole-3-methane sulfonic acid as novel intermediates for the synthesis of zonisamide

专利号:US-7015330-B2
优先权日:2001-08-30
标题:Sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms
发明人：NIDAM TAMAR; MENDELOVICI MARIOARA; SCHWARTZ EDUARD; WIZEL SHLOMIT
权利人:TEVA PHARMA
摘要:The present invention relates to a novel sulfonation of an intermediate of zonisamide. The sulfonation processes using chlorosulfonic acid as well as acetic anhydride and sulfuric acid in an organic solvent are disclosed. Crystalline forms of benzisoxazole methane sulfonic acid (BOS—H) and its salts (BOS—Na, BOS—Ca, and BOS—Ba) and their novel preparation processes are disclosed.

专利号:US-6841683-B2
优先权日:2001-08-30
标 题:Sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms
发明人：MENDELOVICI MARIOARA; NIDAM TAMAR; SCHWARTZ EDUARD; WIZEL SHLOMIT
权利人:TEVA PHARMA
摘要:The present invention relates to a novel sulfonation of an intermediate of zonisamide. The sulfonation processes using chlorosulfonic acid as well as acetic anhydride and sulfuric acid in an organic solvent are disclosed. Crystalline forms of benzisoxazole methane sulfonic acid (BOS-H) and its salts (BOS-Na, BOS-Ca, and BOS-Ba) and their novel preparation processes are disclosed.

专利号:CN-106810507-A
优先权日:2017-01-23
标题 :Environment-friendly synthesis method of zonisamide