CAS: 35065-28-2; 2,2',3,4,4',5'-Hexachloro-1,1'-Biphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由碳,氢和氯原子组成的合成有机化学品组成,其特点是双联体结构,其中两个苯环由一个单一的链接连接在一起,氯原子在环上特定位置被替换.PCB 138通常共含有六种氯原子,影响其物理和化学特性,如稳定性,疏水性和抗降解性.该化合物以其高热稳定性和低挥发性而著称,使其在各种工业应用中有用,包括电气设备和热传导液.然而,多氯联苯,包括PCB138,因其在环境中的持久性和生物生物累积潜力被确认为环境污染物.它们与各种健康风险有关,包括内分泌干扰和致癌效应,导致对其使用和处置的监管限制.

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CAS号636-30-6 2,4,5-三氯苯胺 | CAS号120-82-1 1,2,4-三氯苯 | CAS号87-61-6 1,2,3-三氯苯 | CAS号83704-36-3 1,3,4,6,7-penta...

合成工艺路线路线简述

    📜2,4,5-三氯苯胺,三氯苯置于亚硝酸异戊酯体系中,化学反应生成2,2,3,4,4,5-六氯联苯
    参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
    标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
    摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
    Doi:10.1016/0045-6535(95)00140-4

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    主要参考文献

    [参考文献]: G M Lackmann, Et Al. Parental Smoking And Neonatal Serum Levels Of Polychlorinated Biphenyls And Hexachlorobenzene. Pediatr Res. 2000 May;47(5):598-601.
    [参考文献]: Helena Bjermo, Et Al. Fish Intake And Breastfeeding Time Are Associated With Serum Concentrations Of Organochlorines In A Swedish Population. Environ Int. 2013 Jan:51:88-96.
    [参考文献]: Juan P Arrebola, Et Al. Associations Of Accumulated Exposure To Persistent Organic Pollutants With Serum Lipids And Obesity In An Adult Cohort From Southern Spain. Environ Pollut. 2014 Dec:195:9-15.
    [参考文献]: K Haraguchi, Et Al. Species Differences In The Tissue Distribution Of Catechol And Methylsulphonyl Metabolites Of 2,4,5,2',5'-Penta- And 2,3,4,2',3',6'-Hexachlorobiphenyls In Rats, Mice, Hamsters And Guinea Pigs. Xenobiotica. 2005 Jan;35(1):85-96.
    [参考文献]: Laura Marabini, Et Al. Genotoxic Effects Of Polychlorinated Biphenyls (Pcb 153, 138, 101, 118) In A Fish Cell Line (Rtg-2). Toxicol In Vitro. 2011 Aug;25(5):1045-52.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    摘要:S132 | UJIGCAPCICCS | A GC-APCI-IMS-HRMS CCS Library from Izquierdo-Sandoval et al. (2022) | DOI:10.5281/zenodo.15831151
    参考文献:10.1016/j.toxlet.2018.04.029
    摘要:Kim YA, Kim HY, Oh YJ, Kwon WY, Lee MH, Bae JY, Woo MS, Kim JM, Yoo YH. Polychlorinated biphenyl 138 exposure-mediated lipid droplet enlargement endows adipocytes with resistance to TNF-α-induced cell death. Toxicol Lett. 2018 Aug;292():55–62. doi: 10.1016/j.toxlet.2018.04.029.
    参考文献:10.1007/s00244-018-0528-8
    摘要:Devi NL, Yadav IC, Chakraborty P, Shihua Q. Polychlorinated Biphenyls in Surface Soil from North-East India: Implication for Sources Apportionment and Health-Risk Assessment. Archives of Environmental Contamination and Toxicology. 2018 Apr 30;75(3):377–89. doi: 10.1007/s00244-018-0528-8.
    参考文献:10.1016/j.fct.2008.04.012
    摘要:Radice S, Chiesara E, Fucile S, Marabini L. Different effects of PCB101, PCB118, PCB138 and PCB153 alone or mixed in MCF-7 breast cancer cells. Food Chem Toxicol. 2008 Jul;46(7):2561–7. doi: 10.1016/j.fct.2008.04.012.
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