CAS: 303-14-0; N,N-Dimethyl-2-(10H-Phenothiazin-10-yl)Propan-1-Amine

英文名称N,N-Dimethyl-2-(10H-Phenothiazin-10-yl)Propan-1-Amine
中文名称N,N-二甲基-2-(10H-吩噻嗪-10-基)丙-1-胺
其它别名Phenothiazine,10-[2-(dimethylamino)-1-methylethyl]- (6CI,7CI,8CI); 10-(2-Dimethylaminoisopropyl)phenothiazine; Fen-Bridal; Isomethazine; Isophenergan; Isopromethazine; N-[2-(Dimethylamino)-1-methylethyl]phenothiazine; Prothiazin
CAS编号303-14-0
MFCD编号:MFCD22460468
FDA UNII编号:044033O3TY
分子式:C17H20N2S分子量:284.42
产品CID: 1287190
产品分类有机原料→分子砌块→芳杂环类化合物→其它芳杂环类化合物

相似结构搜索
InChIKey: CGNHCKZJGQDWBG-UHFFFAOYNA-N
1S/C17H20N2S/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
计算化学: 氢键受体数3.0氢键供体数*可旋转键数3.0

物理性质

沸点403.4±34.0 °C at 760 mmHg
闪点197.8±25.7 °C
密度1.1±0.1 g/cm3
PSA:6.48
LogP:4.2394
折射率1.622
溶解性Chloroform (Slightly), Methanol (Slightly, Sonicated)
外观形态浅米色至浅棕色固体
储存条件2-8°C, protect from light

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
安全声明H303+H313+H333

上下游产品

N,N,β-Trimethyl-10H-Phenothiazine-10-α-Oxoethanamine 86382-43-6
异丙嗪 Promethazine 60-87-7
吩噻嗪 10H-Phenothiazine 92-84-2

合成工艺路线路线简述

92-84-2 + 4584-49-0 = 303-14-0
反应条件:1.1 Reagents: Potassium Hydroxide
标题:A Convenient Procedure For The Synthesis Of Phenothiazine Drugs
作者:Galons,Herve; Miocque,Marcel; Combet-Farnoux,Claude; Bensaid,Younes; Decodts,Guy; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1985 卷标:33(11) 页码:5108-9]

86382-43-6 = 303-14-0 [标题:Reaction Conditions
标题:Synthesis Of Isopromethazine Hydrochloride
作者:Fry,Fred S. Jr.; Maienthal,Millard; Benson,Walter R.
参考文献:Journal Of Pharmaceutical Sciences 日期:1983 卷标:72(5) 页码:568-9

📜N,N,β-Trimethyl-10H-Phenothiazine-10-α-Oxoethanamine 以72%的收率获得产物
参考文献:Fry,F. S.,,Jr;Maienthai,M.;Benson,W. R.,J. Pharm. Sci.,1983,72,N 5,568-569
标题:Fry,F. S.,,Jr;Maienthai,M.;Benson,W. R.,J. Pharm. Sci.,1983,72,N 5,568-569