CAS: 29681-44-5; Methyl 5-Bromonicotinate

相似化合物

113118-81-3 20826-04-4 37669-64-0

上下游产品

methanol 5-bromonicotinoyl chloride diazomethane 5-bromo-3-pyridinecarboxylic acid5-bromonicotinic acid hydrazide Methyl 5-(2-Furyl)nicotinate Methyl 5-(3-Furyl)nicotinate 3-(3-nitrophenyl)-5-pyridinecarboxylic acid methyl ester

烟酰氯置于溴体系中,用 二氯甲烷 用作溶剂,化学反应 1.5H,反应生成5-溴烟酸甲酯
参考文献:A General Synthesis Of 5-Arylnicotinates
标题:A General Synthesis Of 5-Arylnicotinates
摘要:
Doi:10.1021/jo00200A045

专利信息

专利号:US-9549921-B2
优先权日:2013-06-24
标 题:Heterocyclic compounds and methods of use thereof for the treatment of hepatitis C
发明人：HE SHUWEN; LAI ZHONG; DAI XING; XIAO DONG; LONDON CLARE; ZORN NICOLAS; NARGUND RAVI; PALANI ANANDAN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD
权利人:HE SHUWEN; LAI ZHONG; DAI XING; XIAO DONG; LONDON CLARE; ZORN NICOLAS; NARGUND RAVI; PALANI ANANDAN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.(I)

专利号:US-9820979-B2
优先权日:2011-07-13
标 题:FXR (NR1H4) binding and activity modulating compounds
发明人：KINZEL OLAF; STEENECK CHRISTOPH; KREMOSER CLAUS
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-2018065917-A1
优先权日:2016-09-02
标 题 :Immune checkpoint inhibitors, compositions and methods thereof
发明人：WEBBER STEPHEN E; ALMASSY ROBERT J
权利人:POLARIS PHARMACEUTICALS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula (I) compounds R 1 , R 2 , X 1 , Y 1 and n are as defined in the specification. The inventive Formula (I) compounds are inhibitors of the PD-1/PD-L1 protein/protein binding or functional interaction and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer and infectious diseases.

专利号:CN-103626693-B
优先权日:2012-08-28
标题:A class of pleuromutilin derivatives, its pharmaceutical composition and its synthesis method and application

专利号:CN-103626693-A
优先权日:2012-08-28
标 题 :A class of pleuromutilin derivatives, its pharmaceutical composition and its synthesis method and application

专利号:CN-116120226-A
优先权日:2022-12-28
标 题 :Synthesis process of 5-hydroxymethyl nicotinonitrile