CAS: 28822-73-3; 4-(1,2-Dihydroxyethyl)Benzene-1,2-Diol

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CAS号100434-10-4 rac 3,4-Bis(ben... | CAS号5447-02-9 3,4-二苄氧基苯甲醛

📜羟基酪醇置于sodium Tetrahydroborate,高氯酸,酪氨酸酶体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 0.03H,反应生成Dl-3,4-二羟基苯基二醇
参考文献:从儿茶酚胺代谢产物衍生的邻喹诺酮类的代谢命运.
标题:从儿茶酚胺代谢产物衍生的邻喹诺酮类的代谢命运.
摘要:邻奎宁酮是通过酶(例如酪氨酸酶)或过渡金属离子氧化邻苯二酚底物而在体内产生的.神经黑素是存在于大脑黑质和大脑蓝斑中的一种深色色素,是通过多巴胺(da)和去甲肾上腺素(ne)与半胱氨酸的相互作用而产生的,但它也掺入了它们的酒精和酸性代谢产物.在这项研究中,我们研究了儿茶酚胺代谢物,3,4-二羟基苯基乙醇(dope),3,4-二羟基苯基乙二醇(dopeg),3,4-二羟基苯基乙酸(dopac)和3,4衍生的邻醌的代谢命运.-二羟基苯基扁桃酸(doma).蘑菇酪氨酸酶氧化邻苯二酚底物,然后进行紫外可见分光光度法.用nabh 3或抗坏血酸还原后进行HPLC分析,可以测量邻醌的半衰期并鉴定其反应产物.分光光度检查表明,最初形成的邻醌在ph 6.8时发生了广泛的降解.HPLC分析表明,Dope-醌和dopeg-醌在ph 6.8下分别以15和30分钟的半衰期降解,在ph 5.3下> 100分钟的半衰期
Doi:10.3390/ijms17020164

专利信息

专利号:US-5648489-A
优先权日:1994-05-17
标题 :Syntheses of acyclic guanine nucleosides
发明人：CHU CHUNG K; DU JINFA; WANG CHUNGUANG
权利人:UNIV GEORGIA
摘要:A method is provided for the synthesis of synthesis of acyclic purine nucleosides, particularly 9-(2-hydroxy-ethoxymethyl)-guanine (acyclovir) and 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine ('DHPG') where the N2,N9-diprotected guanine is reacted with CH3C(O)OCH2O(CH2)2)OC(O)CH3 or 2-acetoxymethoxy-1,3-diacetoxypropane, respectively, in the presence of a mixture of an acid and acetic anhydride, or in the presence of an acid, where the acid can be phosphoric acid or polyphosphoric acid.

专利号:US-2018222848-A1
优先权日:2015-08-04
标 题:Salt of Dihydrophenylglycine Methyl Ester
发明人：VAN DER DOES THOMAS; MOODY HAROLD MONRO; LI WEIDONG
权利人:DSM SINOCHEM PHARM NL BV
摘要:The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics.

专利号:US-5780617-A
优先权日:1990-05-29
标题 :Synthesis of liponucleotides
发明人：VAN DEN BOSCH HENK; VAN WIJK GYSBERT M T; KUMAR RAJ; HOSTETLER KARL Y
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:A process for the preparation of glycerol di- or triphosphate derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

专利号:WO-9118914-A1
优先权日:1990-05-29
标题:Synthesis of glycerol di- and triphosphate derivatives
发明人：VEN DEN BOSCH HENK; VAN WIJK BERT; KUMAR RAJ; HOSTETLER KARL Y
权利人:VICAL INC
摘要:A process for the preparation of glycerophospholipid derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

专利号:US-2010247433-A1
优先权日:2005-10-14
标题:Use of non-canonical amino acids as metabolic markers for rapidly-dividing cells
发明人：TIRRELL DAVID; DIETERICH DANIELA C; LINK AARON J; SCHUMAN ERIN
权利人:CALIFORNIA INST OF TECHN
摘要:The invention provides methods, reagents and systems to preferentially mark fast-proliferating cells/tissues (such as cancer), by incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handleâ€? to for a number of uses, such as imaging of cancer cells, targeting drugs to preferentially kill cancer cells, and proteomic analysis in the context of large scale or high throughput screening for candidate drug leads that affects the proliferation of a target cell, etc.

专利号:US-6465634-B1
优先权日:1996-04-05
标题 :Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
发明人：DUBENSKY JR THOMAS W; POLO JOHN M; BELLI BARBARA A; SCHLESINGER SONDRA; DRYGA SERGEY A; FROLOV ILYA
权利人:CHIRON CORP; UNIV WASHINGTON
摘要:Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.