CAS: 2373-31-1; 6-Hydroxy-4-Methyl-2H-Chromen-2-One

该化合物是Coumarin家族的化合物,其特点是苯丙胺结构,该化合物的特点是6位置的氢氧基组和4位置的甲基组,其独特性能有助于Coumarin环的4位置.该化合物通常是在乙醇和甲醇等有机溶剂中可溶解的黄色晶状固体,但水溶性有限. 6-Hydroxy-4-甲基丙氨的浮质展示,使其在各种应用中有用,包括作为生物化学实验中的荧光探针.此外,该化合物的结构还研究其潜在的生物活动,包括抗氧化剂和抗微生物特性.该化合物的结构允许进行各种化学修改,这可以增强其在合成应用中的再活性和功能.应当查阅安全数据,以便处理和使用,如任何化学物质一样,确保采取适当的防范措施.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

methanol deuterated formic acid potassium deuteroformate dimethyl sulfate 6-methoxy-4-methyl-chromen-2-one 6-ethoxycarbonyloxy-4-methyl-coumarin O,O-diethyl-O-(4-methyl-6-coumarino)-phosphorothioate 4-methyl-6-(toluene-4-sulfonyloxy)-coumarin

合成工艺路线路线简述

    6-烯丙氧基-4-甲基-色烯-2-酮置于palladium On Activated Charcoal Ammonium Formate体系中,用 甲醇 用作溶剂,化学反应 1.5H,以95%的收率获得6-羟基-4-甲基香豆素
    参考文献:使用钯/炭催化剂和甲酸铵对苯酚和羟基香豆素的烯丙基醚进行温和有效的脱保护
    标题:使用钯/炭催化剂和甲酸铵对苯酚和羟基香豆素的烯丙基醚进行温和有效的脱保护
    摘要:描述了一种催化量为10%的pd / C与甲酸铵相结合的烯丙基苯基醚和烯丙基香豆基醚裂解的有效方法.酚的烯丙基醚比醇的烯丙基醚优先脱保护,并且该方法与几种可还原的官能团如cho,Coch 3,Co 2 Et和nhcoch 3相容.
    Doi:10.1016/j.Tetlet.2006.05.176

    海关参考信息

    专利信息


    专利号:GB-682457-A
    优先权日:1950-02-02
    标 题 :Synthesis of 4-methylcoumarins

    专利号:US-2013164265-A1
    优先权日:2011-12-21
    标题 :Skin care compositions
    发明人:FLAVIN DANA; OBENLAND SIGRID
    权利人:FLAVIN DANA; OBENLAND SIGRID
    摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

    专利号:US-2014328952-A1
    优先权日:2011-12-21
    标题:Topical compositions
    发明人:FLAVIN DANA
    权利人:FLAVIN DANA
    摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

    专利号:US-8790720-B2
    优先权日:2011-12-22
    标题:Compositions and methods for treating skin
    发明人:RICHARDS JEANETTE ANTHEA; DAWSON THOMAS LARRY; COMBS MARY JANE; DUEVA-KOGANOV OLGA; KOGANOV MICHAEL
    权利人:PROCTER & GAMBLE
    摘要:The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and/or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and/or interrupt an inflammatory cycle.
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    合成参考文献


    摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 182.
    摘要:B. N. Mattoo, Trans. Faraday Soc. 53, 760 (1957).
    参考文献:10.1021/jm990073x
    摘要:Muegge I, Martin YC, Hajduk PJ, Fesik SW. Evaluation of PMF scoring in docking weak ligands to the FK506 binding protein. J Med Chem. 1999 Jul 15;42(14):2498–503. doi: 10.1021/jm990073x.
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