CAS: 192704-56-6; 11-A-Hydroxy Canrenone Methyl Ester

相似化合物

2304869-71-2 2073041-47-9 41020-65-9

上下游产品

CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号74-88-4 碘甲烷 | CAS号192704-54-4 4'S(4'α),7'α-he... | CAS号124-41-4 甲醇钠 | CAS号865-33-8 甲醇钾 | CAS号41020-65-9 Mexrenone | CAS号192569-17-8 11α-羟基坎利酮 | CAS号1398078-09-5 11β,17β-dihydro... | CAS号95716-70-4 孕烯羧酸内酯 | CAS号107724-20-9 依普利酮

11-Alpha-羟基坎利酮置于十八烷基二甲基苄基氯化铵,Potassium Carbonate,Sodium Nitrite体系中,用 N,N-二甲基甲酰胺,丙酮 用作溶剂,化学反应 53.5H,反应生成11A-羟基坎利酮丙烯酸甲酯
参考文献:一种坎利酮衍生物类甾体化合物,其制备方法 及其在制备依普利酮中的用途
标题:一种坎利酮衍生物类甾体化合物,其制备方法 及其在制备依普利酮中的用途
摘要:本发明涉及一种坎利酮衍生物类甾体化合物,其制备方法和其在医药领域中的用途,具体而言,涉及7α-硝基甲基-11α,17β-二羟基-3-氧代-17α-孕甾-4-烯-21-羧酸-γ-内酯(式2所示的化合物),其制备方法以及其在制备依普利酮中的用途.本发明的关键步骤在于以硝基甲烷作为亲核试剂,立体选择性在c-7位引入α-硝基甲基,从而进一步构建依普利酮c-7α位构型的羧酸甲酯结构,具有步骤简短,条件温和,成本低廉的特点.

专利信息

专利号:US-6610844-B2
优先权日:1996-12-11
标题:Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
发明人：NG JOHN S; LIU CHIN; ANDERSON DENNIS K; LAWSON JON P; WIECZOREK JOSEPH; KUNDA SASTRY A; LETENDRE LEO J; POZZO MARK J; SING YUEN-LUNG L; WANG PING T; YONAN EDWARD E; WEIER RICHARD M; KOWAR THOMAS R; BAEZ JULIO A; ERB BERNHARD
权利人:SEARLE & CO
摘要:Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein-A-A- represents the group -CHR4-CHR5- or -CR4=CR5-;R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano and aryloxy;R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical;-B-B- represents the group -CHR6-CHR7- or an alpha- or beta-oriented group:where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; andR8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.

专利号:US-7129345-B2
优先权日:1995-12-11
标题:Keto-substituted steroid compounds
发明人：NG JOHN S; WANG PING T; BAEZ JULIO A; LIU CHIN; ANDERSON DENNIS K; LAWSON JON P; ERB BERNHARD; WIECZOREK JOSEPH; MUCCIARIELLO GENNARO; VANZANELLA FORTUNATO; KUNDA SASTRY A; LETENDRE LEO J; POZZO MARK J; SING YUEN-LUNG L; YONAN EDWARD E
权利人:PHARMACIA CORP
摘要:Multiple novel keto-substituted intermediates are provided for the synthesis of epoxymexrenone, useful as an Aldosterone Receptor Antagonist.