CAS: 1792-81-0; Cis-1,2-Cyclohexanediol

该化合物是一种双循环有机化合物,其特点是,环氧环中相邻碳原子有两个顺质的氢氧(-OH)组,其分子结构具有六种碳环,其六种碳环与位于环的同一侧的氢氧基组,这显示了其"cis"配置.这种立体化学影响其物理特性,如溶性与沸点.Cis-1-2-Cyclohexanediol在室温中一般是一种无色,粘性液体或固体,表现出氢氧基组的中度极性.它溶于水和各种有机溶剂中,在化学合成中有用,并且作为其他化合物生产的中间体.该化合物还有助于有关立体化学学和分子相互作用的研究.安全数据表明,尽管它可能构成某些健康风险,但一般认为它具有低毒性.建议适当处理和储存以确保实验室环境的安全.

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    专利信息


    专利号:US-9981935-B2
    优先权日:2013-07-05
    标 题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of acids
    发明人:MEDLOCK JONATHAN ALAN; LETINOIS ULLA; NETSCHER THOMAS; BONRATH WERNER
    权利人:DSM IP ASSETS BV
    摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.

    专利号:US-2004049049-A1
    优先权日:2002-06-14
    标 题 :Stereoselective synthesis of 1,2-disubstituted cycloalkyls
    发明人:JURAYJ JURJUS F; FARHAN EMILE; SHARMA PRADEEP K
    权利人:JOHNSON MATTHEY PHARMACEUTICAL
    摘要:A stereoselectively method of preparing a 1,2-disubstituted cycloalkyl, such as aminocycloalkyl ether compounds, from a trans-1,2-disubstituted cycloalkyl or a cis-2-substituted cycloalkanol. For example, a stereoselective method of preparing 1R-(3R-hydroxypyrrolidin-1-yl)-2R-(2-phenylethoxy)-cyclohexane from 1R,2R-cyclohexanediol or from meso-cis-1,2-cyclohexanediol is described. Aminocycloalkyl ethers, such as 1R-(3R-hydroxypyrrolidin-1-yl)-2R-(2-phenylethoxy)-cyclohexane, can be used to treat cardiac disease.

    专利号:US-12252583-B2
    优先权日:2018-06-20
    标题:Method of making mixture of polymers
    发明人:FONTANA GIOVANNI; GALIMBERTI MARCO; TORTELLI VITO
    权利人:SOLVAY SPECIALTY POLYMERS IT
    摘要:The present invention relates to a process for the synthesis of partially and fully fluorinated polyether (PFPE) polymers comprising cyclic moieties in the backbone chain, to PFPE polymers obtained therefrom and to the use of said PFPE polymers as intermediate compounds for the manufacture of additives for plastic and glass coating.

    专利号:US-7456298-B2
    优先权日:2002-06-03
    标题:Synthesis of acetonides from aryl silanes
    发明人:MCAULIFFE JOSEPH C; WHITED GREGORY M; SMITH WYATT CHARLES
    权利人:GENENCOR INT
    摘要:The present invention is related to cis-diols and biological methods of producing cis-diols. The present invention further relates to processes for subsequently converting such silane cis-diols to the more stable acetonide derivatives, as well as a process for converting silane cis-diols to the corresponding catechols and the compounds produced thereby. The present invention also provides chemical methods for the conversion of said silane cis-diols and acetonide compounds to epoxy, saturated and otherwise modified derivatives. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims.

    专利号:US-9051656-B2
    优先权日:2009-07-23
    标题 :Electrochemical synthesis of aryl-alkyl surfacant precursor
    发明人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI
    权利人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI; CERAMATEC INC
    摘要:An aryl-alkyl (R—Ar) hydrocarbon is prepared by an electrosynthesis process in an electrolytic cell having an alkali ion conductive membrane positioned between an anolyte compartment configured with an anode and a catholyte compartment configured with a cathode. An anolyte solution containing an alkali metal salt of an alkyl carboxylic acid and an aryl compound is introduced into the anolyte compartment. The aryl compound may include an alkali metal salt of an aryl carboxylic acid, an arene (aromatic) hydrocarbon, or an aryl alkali metal adduct (Ar − M + ). The anolyte solution undergoes electrolytic decarboxylation to form an alkyl radical. The alkyl radical reacts with the aryl compound to produce the aryl-alkyl hydrocarbon.

    专利号:US-2004033574-A1
    优先权日:2002-06-03
    标题 :Synthesis of cis-diols from aryl silanes

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: A Perico, Et Al. Biological Monitoring Of Occupational Exposure To Cyclohexane By Urinary 1,2- And 1,4-Cyclohexanediol Determination. Int Arch Occup Environ Health. 1999 Mar;72(2):115-20.
    [参考文献]: J Mráz, Et Al. Effect Of Ethanol On The Urinary Excretion Of Cyclohexanol And Cyclohexanediols, Biomarkers Of The Exposure To Cyclohexanone, Cyclohexane And Cyclohexanol In Humans. Scand J Work Environ Health. 1999 Jun;25(3):233-7.
    [参考文献]: Kango Fujitani, Et Al. Oxidation Of Cyclohexanediol Derivatives With 12-Tungstophosphoric Acid-Hydrogen Peroxide System. J Oleo Sci. 2009;58(6):323-8.
    [参考文献]: Keiji Yamamoto, Et Al. Absence Of Interactive Effects Of Trans-1,2-Cyclohexanediol, A Major Metabolite Of The Side-Chain Of Candesartan Cilexetil, On Digoxin-Induced Arrhythmias In Dogs. J Pharmacol Sci. 2003 Aug;92(4):387-99.
    [参考文献]: R J Swift, Et Al. Expression Of Benzene Dioxygenase From Pseudomonas Putida Ml2 In Cis-1,2-Cyclohexanediol-Degrading Pseudomonads. Appl Microbiol Biotechnol. 2001 Jun;55(6):721-6.

    合成参考文献


    摘要:Carbery, D., Science of Synthesis Knowledge Updates, (2010) 3, 153.
    摘要:Vandamme, M.; Paquin, J.-F., Science of Synthesis Knowledge Updates, (2016) 1, 401.
    摘要:Vashchenko, B. V.; Grygorenko, O. O., Science of Synthesis Knowledge Updates, (2021) 3, 329.
    摘要:Smith, A. D.; Woods, P. A., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 570.
    摘要:Smith, A. D.; Woods, P. A., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 575.
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