CAS: 167316-27-0; N-((1S,2S)-2-Amino-1,2-Diphenylethyl)-4-Methylbenzenesulfonamide

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CAS号29841-69-8 (1S,2S)-(-)-1,2... | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号530-36-9 1,2-二苯基-2-氨基乙醇

(1S,2S)-1,2-二苯基乙二胺,对甲苯磺酰氯置于n,N-二异丙基乙胺体系中,用 二氯甲烷 用作溶剂,化学反应生成(1S,2S)-(+)-N-对甲苯磺酰基-1,2-二苯基乙二胺
参考文献:仿生铁催化过氧化氢芳烃的不对称环氧化.
标题:仿生铁催化过氧化氢芳烃的不对称环氧化.
摘要:本文报道了通过使用过氧化氢的新颖且一般的仿生非血红素铁催化的芳族烯烃的不对称环氧化.催化剂由六水合氯化铁(fecl(3)6 H(2)o),吡啶2,6-二羧酸(h(2)(pydic))和易于获得的手性n-芳烃磺酰基-N'-苄基组成取代的乙二胺配体.苯乙烯与该体系的不对称环氧化产生高转化率,但对映体过量(ee)差,而较大的烯烃产生高转化率和ee值.对于反式二苯乙烯(1A)的环氧化,配体(s,S)-N-(4-甲苯磺酰基)-1,2-二苯基乙二胺((s,S)-4 A)及其n'-苄基衍生物((s,S)-5A)得到反式二苯乙烯氧化物的相反对映异构体,分别为(s,S)-2A和(r,R)-2A.烯烃环氧化的对映选择性受空间和电子因素控制,尽管空间作用更为主要.初期机理研究表明,一些手性铁络合物的原位形成,例如[fecl(l *)(2)(pydic)] Hcl(l * =(s,S)-4 A或(s,S)-在催
Doi:10.1002/chem.200800595

专利信息

专利号:US-7247752-B2
优先权日:2004-10-01
标 题 :Methods for the synthesis of astaxanthin
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID
权利人:CARDAX PHARMACEUTICALS INC
摘要:A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.

专利号:WO-2024259491-A1
优先权日:2023-06-23
标 题:New synthesis method
发明人：FORD DANIEL; POZNAKS VIKTORS; FOTINS JURIS; ÄŒERÅ…AKS DMITRIJS
权利人:THE HEART RES INSTITUTE LTD
摘要:The present disclosure generally relates to a process for the synthesis of AZD6482. In particular, the present disclosure also relates to a process for the synthesis of enantiomerically pure AZD6482. The present disclosure also relates to a process for the synthesis of enantiomerically pure intermediates. The present disclosure also relates to compounds prepared by the processes and the use of such compounds to prepare compositions and to treat disorders.

专利号:US-8242277-B2
优先权日:2006-12-12
标题:Preparation of tetrahydroisoquinolines from dihydroisoquinolines
发明人：CANTRELL GARY L; MAGPARANGALAN DAN P; MOSER FRANK W; BAO JIAN; GROTE CHRISTOPHER W; WANG PETER X
权利人:CANTRELL GARY L; MAGPARANGALAN DAN P; MOSER FRANK W; BAO JIAN; GROTE CHRISTOPHER W; WANG PETER X; MALLINCKRODT LLC
摘要:The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.

专利号:US-8471023-B2
优先权日:2009-06-11
标 题:Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
发明人：GROTE CHRISTOPHER W; CANTRELL GARY L; MCCLURG JOSEPH P; THOMASSON CATHERINE E; MOSER FRANK W
权利人:GROTE CHRISTOPHER W; CANTRELL GARY L; MCCLURG JOSEPH P; THOMASSON CATHERINE E; MOSER FRANK W; MALLINCKRODT LLC
摘要:The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.

专利号:US-8415474-B2
优先权日:2009-09-24
标题 :One-pot preparation of hexahydroisoquinolines from dihydroisoquinolines
发明人：GROTE CHRISTOPHER W; MOSER FRANK W; WANG PETER X; CANTRELL GARY L; BERBERICH DAVID W
权利人:GROTE CHRISTOPHER W; MOSER FRANK W; WANG PETER X; CANTRELL GARY L; BERBERICH DAVID W; MALLINCKRODT LLC
摘要:The present invention provides an efficient process for the preparation of hexahydroisoquinolines from dihydroisoquinolines. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.

专利号:US-8519133-B2
优先权日:2009-06-11
标 题 :Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
发明人：GROTE CHRISTOPHER W; CANTRELL GARY L; MCCLURG JOSEPH P; THOMASSON CATHERINE E; MOSER FRANK W
权利人:GROTE CHRISTOPHER W; CANTRELL GARY L; MCCLURG JOSEPH P; THOMASSON CATHERINE E; MOSER FRANK W; MALLINCKRODT LLC
摘要:The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.