CAS: 1404-64-4; (E)-N-((2S)-1-Hydroxy-3-(((Methylthio)Methyl)Sulfinyl)Propan-2-yl)-3-(6-Methyl-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidin-5-yl)Acrylamide

上下游产品

3-(2,4-二氧代-6-甲基-5-嘧啶基)丙烯酸 (E)-β-(2,4-Dioxo-6-Methyl-1,2,3,4-Tetrahydropyrimidin-5-yl)Acrylic Acid 28277-67-0
Ethyl (E)-3-(2,4-Dioxo-6-Methyl-5-Pyrimidinyl)Acrylate 28277-68-1

📜6-甲基-2,4-二氧代-1,2,3,4-四氢-嘧啶-5-甲醛置于n-羟基-7-氮杂苯并三氮唑,四丁基氟化铵,N,N'-二环己基碳二亚胺,Sodium Hydroxide体系中,用 四氢呋喃,1,4-二氧六环,甲醇,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 17.0H,反应生成司帕索霉素
参考文献:通过硫酸盐阴离子介导的迭代 C-S 键形成全合成 Sparsomycin 和 Sparoxomycins A1 和 A2
标题:通过硫酸盐阴离子介导的迭代 C-S 键形成全合成 Sparsomycin 和 Sparoxomycins A1 和 A2
摘要:嘧啶基丙烯酰胺抗生素sparsomycin和sparoxomycins A 1和a 2已实现全合成.稀疏霉素的合成依赖于磺酸根阴离子对卤代烷的反复亲核攻击,构建具有高非对映选择性的二硫缩醛一氧化碳链.随后,通过试剂控制的非对映选择性氧化稀疏霉素的末端硫醚部分,直接得到稀疏霉素a 1和a 2 .
Doi:10.1021/acs.Orglett.3C03791

专利信息

专利号:US-2004126792-A1
优先权日:2002-09-18
标 题 :Synthesis and applications of trinucleotide pCpCpA-3'-NH-aminoacyl derivatives
发明人：ZHANG BILIANG
摘要:The present invention relates to the synthesis of novel compounds for the inhibition of peptide synthesis in the ribosome. It also relates to improved methods for directly monitoring peptide bond formation in the ribosome. These compounds can be used for high throughput screening of proposed therapeutically active drug species (e.g., antibiotics) targeted to ribosomes.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-11466046-B2
优先权日:2014-10-08
标题 :14-membered ketolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.