CAS: 137-86-0; Octotiamine
该化合物是硫胺(维生素B1)的合成衍生物,其特点是其脂溶性增强,与传统硫胺盐相比生物利用率提高;其化学结构以辛醇-辛酸为特征,有利于高效吸收和细胞吸收,使其在解决硫胺缺乏症和相关代谢性失调方面特别有效;八溴二苯醚在生理条件下保持稳定,表现出长期的活动,支持碳水化合物新陈代谢和能源生产中的最佳酶功能;该产品与各种药物配方的兼容性允许在营养学和治疗补充剂中应用多种用途;该化合物具有良好的耐用性,具有有利的安全特征,并经常用于需要持续提供硫胺的临床和营养环境.
- 英文名称Octotiamine
- 中文名称硫辛酸硫胺
- IUPAC名称methyl 6-(acetylthio)-8-((2-(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamido)-5-hydroxypent-2-en-3-yl)disulfaneyl)octanoate
- 其它别名Octotiamine; Gerostop; Neuvitan; Octanoicacid,6-(Acetylthio)-8-((2-(((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)Fo; Octotiamina [inn-Spanish]; Octanoic Acid, 6-(Acetylthio)-8-[[2-[[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]Formylamino]-1-(2-Hydroxyethyl)-1-Propenyl]Dithio]-, Methyl Ester (9Ci); Octiamine; S-(3-Acetylthio-7-Carbomethoxyheptylthio)Thiamine
- CAS编号137-86-0
- FDA UNII编号:UN1Q7096GA
- 分子式:C23H36N4O5S3分子量:544.77
- 产品CID: 588064
- 同类组份化合物CAS1181-74-4 (HCl)137-86-0 (free base)
- 产品分类有机原料 → 有机杂环化合物 → 二嗪类
物理性质
- 熔点106-109°
- 沸点722 °C at 760mmHg
- 闪点390.5 °C
- 密度1.268g/cm3
- PSA:211.61
- LogP:5.3098
- 折射率1.595
- 蒸汽压7.03E-22mmHg at 25°C
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用OCTOTIAMIINE FREAMIN用于治疗脑血管疾病. 含有PEMLINE, PYRIDYLCARBINOL, CLOFIBRATE, NICOTINE 酸, VITAMIN A, B, B 6, B6, E, D 3 & DICALCION 磷酸
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905121000-正丙醇
2905130000-正丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-2005182036-A1
优先权日:2002-08-02
标题:Medicinal composition containing an HMG-CoA reductase inhibitor
发明人：KONDO TATSUHITO; TAKAGI IKUO; NAKAYAMA MASATO; TORIZUMI YASUHIRO
权利人:SANKYO CO
摘要:A pharmaceutical composition for promoting the synthesis of vascular endothelial nitrogen oxide and/or maintaining or elevating the concentration of vascular endothelial nitrogen oxide in the blood, or a pharmaceutical composition for improving blood lipids. The pharmaceutical composition contains an HMG-CoA reductase inhibitor; and gamma-oryzanol, and/or thiamines. For treatment, the components of the composition can be administered together, as a composition, or separately.
供应商参考报价(招募中)
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📌 第三方产品分析报告
主要参考文献
1: Tomozawa H, Momonaga M, Uemura T, Yazawa H. Influence of powder characteristics of bulk substance with pharmaceutical processing. Drug Dev Ind Pharm. 1998 Sep;24(9):857-61. doi: 10.3109/03639049809088531.
合成参考文献
摘要:Drugs in Japan, 6(159), 1982
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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