CAS: 128107-47-1; Fmoc-D-Ser(Tbu)-Oh

相似化合物

71989-33-8 1210833-53-6 205812-07-3

上下游产品

O-tert-butyl-L-serine methyl ester N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimidetert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid pentafluorophenyl ester3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid pentafluorophenyl ester tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-nitro-phenyl ester3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-nitro-phenyl ester benzyloxycarbonylmethyl 3-O-((R)-3-benzyloxytetradecanoyl)-2-((R)-3-benzyloxytetradecanoylamino)-2-deoxy-6-O-(N-(9-fluorenylmethoxycarbonyl)-O-tert-butyl-D-seryl)-α-D-glucopyranoside [(N-o-methylbenzoyl-O-tert-butyl)-D-seryl]-L-alanine

📜H-Ser(Tbu)-甲氧基盐酸盐,9-芴甲基-N-琥珀酰亚胺基碳酸酯置于sodium Carbonate体系中,用 乙酸乙酯 用作溶剂,以71.5%的收率获得fmoc-O-叔丁基-D-丝氨酸
参考文献:一种n-(9-芴甲氧羰基)-O-叔丁基-L-丝氨酸的制备方法
标题:一种n-(9-芴甲氧羰基)-O-叔丁基-L-丝氨酸的制备方法
摘要:本发明公开了一种n‑(9‑芴甲氧羰基)‑o‑叔丁基‑l‑丝氨酸的制备方法,包括:(A)向反应容器中加入l‑丝氨酸和甲醇溶液,在搅拌下滴加socl2,回流反应,得到l‑丝氨酸甲酯盐酸盐;(B)将l‑丝氨酸甲酯盐酸盐加入到醋酸叔丁酯中,加入催化剂,反应,得到o‑叔丁基‑l‑丝氨酸甲酯;(C)将o‑叔丁基‑l‑丝氨酸甲酯加入到碱液中,皂化反应,得到o‑叔丁基‑l‑丝氨酸水溶液;(D)向o‑叔丁基‑l‑丝氨酸中加入有机溶剂和na2Co3,再加入芴甲氧羰酰琥珀酰亚胺,调节ph值至8‑10,萃取分离,得到n‑(9‑芴甲氧羰基)‑o‑叔丁基‑l‑丝氨酸.本发明的制备方法中,采用l‑丝氨酸,甲醇和socl2作为原料,通过回流反应,制备l‑丝氨酸甲酯盐酸盐;反应均在液相中进行,安全无污染.

专利信息

专利号:US-11634741-B2
优先权日:2013-11-20
标 题:Synthesis of L-nucleic acids by means of an enzyme
发明人：PECH ANDREAS; JAROSCH FLORIAN; JAHNZ MICHAEL; KLUSSMANN SVEN; DAVID RALF
权利人:APTARION BIOTECH AG
摘要:The present invention is related to a method for adding one or more L-nucleotides to the 3′end of a first L-nucleic acid, wherein the method comprises the step of reacting the one or more L-nucleotides with the first L-nucleic acid in the presence of a protein comprising a mutant enzymatic activity exhibiting moiety, wherein the enzymatic activity is capable of adding one or more L-nucleotides to the 3′ end of the first L-nucleic acid, wherein the mutant enzymatic activity exhibiting moiety comprises an amino acid sequence, wherein the amino acids of the amino acid sequence are D-amino acids, wherein the mutant enzymatic activity exhibiting moiety is a variant of an enzymatic activity exhibiting moiety, wherein the enzymatic activity exhibiting moiety consists of an amino acid sequence according to SEQ ID NO: 15 and wherein the amino acids of the amino acid sequence according to SEQ ID NO: 15 are D-amino acids, wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety differs from the amino acid sequence of the enzymatic activity exhibiting moiety consisting of an amino acid sequence according to SEQ ID NO: 15 at least at one amino acid position, preferably at three amino acid positions, and/or wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is a truncated form of an amino acid sequence according to SEQ ID NO: 15, and wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is different from an amino acid sequence according to any of SEQ ID NOs 15 to 22 and 51.

专利号:US-2018208910-A1
优先权日:2012-05-16
标 题 :Enzymatic Synthesis of L-Nucleic Acids

专利号:EP-3071702-B1
优先权日:2013-11-20
标题 :Synthesis of l-nucleic acids by means of an enzyme

专利号:US-2016304926-A1
优先权日:2013-11-20
标题:Synthesis of L-Nucleic Acids by Means of an Enzyme

专利号:EP-2850192-B1
优先权日:2012-05-16
标 题 :Enzymatic synthesis of l-nucleic acids

专利号:ES-2965777-T3
优先权日:2012-05-16
标 题:Enzymatic synthesis of L-nucleic acids