CAS: 12640-73-2; 1,2,4-Trihydroxy-9,10-Anthraquinone

专利信息

专利号:US-6093739-A
优先权日:1997-11-21
标 题:Synthesis of long wavelength absorbing photosensitizers
发明人：JOHNSON CLAIRE K; DOLPHIN DAVID
权利人:UNIV BRITISH COLUMBIA
摘要:The present invention provides for novel therapeutic macrocycle compounds useful in photodynamic therapy that are based on the chlorin ring system. The macrocycle compounds have, in many cases, wavelengths of activation at about 670 nm, characteristics of chlorins, and are stabilized against oxidation by the attachment to the chlorin ring of a structure that comprises one or more exocyclic rings that contribute at least one nitrogen atom. Protonation or covalent modification of this nitrogen atom, or other covalent modification of the one or more exocyclic rings permits optimization of pharmacalogically relevant properties including, for example, solubility. Representative chlorins include the pyridochlorins depicted as follows ##STR1##

专利号:US-9017974-B2
优先权日:2011-06-06
标题:Method for the synthesis of porphyrin-phospholipid conjugates
发明人：ZHENG GANG; LOVELL JONATHAN
权利人:ZHENG GANG; LOVELL JONATHAN; UNIV HEALTH NETWORK
摘要:There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.

专利号:US-5864035-A
优先权日:1996-03-08
标 题:Synthesis of isoimide of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
发明人：PANDEY RAVINDRA K; KOZYREV ANDREI N; DOUGHERTY THOMAS J
权利人:HEALTH RESEARCH INC
摘要:Compounds having utility as light absorbing compounds, especially in the area of photodynamic therapy. Such compounds have the formula: ##STR1## where z is â•?O or NR 14 ; R 14 is alkyl or substituted alkyl; R 1 is an amino acid group, a polyamine group, a polyether group or OR 13 where R 13 is alkyl; R 4 through R 11 are --H, --OH alkyl, alkoxy, alkenyl, alkylene, aryl, or aryloxy, or a carbonyl containing group, wherein carbon containing groups may be substituted with carbonyl, hydroxy, phosphoro, carboxy, halo, sulfo, amino and ether substituents, provided that; R 4 may be taken together with R 7 to form â•?O; R 8 may be taken together with R 9 to form â•?O; R 10 may be taken together with R 11 to form â•?O; and R 4 and R 7 may together form a chemical bond and R 8 and R 11 may together form a chemical bond; and R 12 is hydrogen or lower alkyl; provided that if one z is O, the other z is --NR 14 .

专利号:US-12007376-B2
优先权日:2014-02-26
标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample
发明人：LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M
权利人:TRACE ABILITY INC
摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.

专利号:US-2023097824-A1
优先权日:2020-05-08
标 题:Semi-synthesis and use of racemic hematoxylin
发明人：DURRANT EDWARD E; HEINDL DIETER; HUBER FLORIAN MAURITIUS ERASUMU; KLEIN ERIC; KOSMEDER II JEROME W; VOSS EDGAR
权利人:VENTANA MED SYST INC; ROCHE DIAGNOSTICS OPERATIONS INC
摘要:A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.

专利号:US-10772990-B2
优先权日:2014-04-01
标题 :Tissue filler compositions and methods of use
发明人：NIKOLIS ANDREAS; HERBERT LISE
权利人:KLOX TECH INC
摘要:The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.