4-硝基苯磺酰氨基-6-甲氧基嘧啶置于铁粉,氯化铵体系中,用 水 用作溶剂,化学反应 10.0H,反应生成磺胺间甲氧嘧啶 参考文献:P-Nitrobenzenesulfonyl Chloride As A Raw Material For The Manufacture Of Sulfanilamide Preparations 标题:P-Nitrobenzenesulfonyl Chloride As A Raw Material For The Manufacture Of Sulfanilamide Preparations 摘要: Doi:10.1007/bf01156380
专利号:US-9693999-B2 优先权日:2011-01-26 标题:Small molecule RNase inhibitors and methods of use 发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE 权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education 摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
专利号:US-9439423-B2 优先权日:2007-10-29 标 题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites 发明人:KAWANO FUMI; HIRAZAWA NORITAKA 权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD 摘要:An antiparasitic agent for fish includes an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is disclosed. Sulfonamide is disclosed as suitable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist are disclosed as suitable inhibitors of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is effective against fish parasites belonging to the ciliate group.
专利号:US-9265777-B2 优先权日:2009-04-27 标题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites 发明人:KAWANO FUMI; HIRAZAWA NORITAKA 权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD 摘要:A method of controlling proliferation of fish parasites comprising the administration of 1 to 50 mg/kg fish body weight/day of an inhibitor of folate synthesis and/or an inhibitor of folate activation to fish continuously for 1 to 2 weeks. Using a combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is preferable, and a sulfonamide is preferable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist, etc., can be used as the inhibitor of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is particularly effective against parasites belonging to the ciliate group among fish parasites.
专利号:WO-2009056955-A1 优先权日:2007-10-30 标题 :Amine-bearing phospholipids (abps), their synthesis and use 发明人:ZUMBUEHL ANDREAS 权利人:UNIV BASEL; ZUMBUEHL ANDREAS 摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.
专利号:US-9868747-B2 优先权日:2014-02-18 标题:Marinopyrrole derivatives and methods of making and using same 发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI 权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD 摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
专利号:BR-102022013818-A2 优先权日:2022-07-12 标 题:SYNTHESIS OF MOLECULARLY PRINTED BIFUNCTIONAL HYBRID POLYMER POLY(METHACRYLIC ACID-PHENYLTRIMETHOXYSILANE) AND EVALUATION AS AN ADSORBENT FOR DIURON EXTRACTION IN AQUEOUS MEDIUM
1: Song C, Li L, Zhang C, Kamira B, Qiu L, Fan L, Wu W, Meng S, Hu G, Chen J. Occurrence and human dietary assessment of sulfonamide antibiotics in cultured fish around Tai Lake, China. Environ Sci Pollut Res Int. 2017 Jun 7. doi: 10.1007/s11356-017-9442-2. [Epub ahead of print] doi: 10.1016/j.biortech.2017.04.023. Epub 2017 Apr 9. doi: 10.1080/03601234.2017.1293457. Epub 2017 Mar 10. doi: 10.1016/j.aca.2017.01.052. Epub 2017 Feb 1. doi: 10.1002/elps.201600364. Epub 2016 Nov 28. Chinese. Chinese. doi: 10.1016/j.chemosphere.2016.07.009. Epub 2016 Jul 15. doi: 10.1016/j.neulet.2016.05.007. Epub 2016 May 9. doi: 10.1177/0960327116646839. Epub 2016 Jul 11. doi: 10.1016/j.envpol.2016.02.043. Epub 2016 Mar 4. doi: 10.5740/jaoacint.13-133. doi: 10.1016/j.scitotenv.2015.02.100. Epub 2015 Mar 13. doi: 10.1007/s00216-015-8503-y. Epub 2015 Mar 3. doi: 10.1016/j.foodchem.2015.01.076. Epub 2015 Jan 21. doi: 10.1016/j.foodchem.2014.11.133. Epub 2014 Nov 28. doi: 10.1080/10934529.2015.975062. doi: 10.1016/j.etap.2014.09.006. Epub 2014 Sep 16.
合成参考文献
摘要:Oyo Yakuri. Pharmacometrics., 9(133), 1975 摘要:Strahlentherapie., 127(245), 1965 [] 摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664 参考文献:10.1002/bies.10114 摘要:Bermingham A, Derrick JP. The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays. 2002 Jul;24(7):637–48. doi: 10.1002/bies.10114.