专利号:US-8871975-B2 优先权日:2011-01-05 标题 :Process for the synthesis of agomelatine 发明人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI 权利人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI; SERVIER LAB 摘要:Process for the industrial synthesis of the compound of formula (I)
专利号:US-8212077-B2 优先权日:2008-08-05 标 题:Process for the synthesis of agomelatine 发明人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS 权利人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS; SERVIER LAB 摘要:Process for the industrial synthesis of the compound of formula (I)
专利号:US-7030230-B2 优先权日:2002-10-25 标题:Process of purifying phosphoramidites 发明人:ROSS BRUCE; SONG QUANLAI 权利人:ISIS PHARMACEUTICALS INC 摘要:A process of purifying phosphoramidite precursors useful in inter alia synthesis of oligonucleotides comprises dissolving a crude phosphoramidite in a polar phase, adding a basic compound to the polar phase, adding a portion of water to the polar phase, contacting the polar phase with a first apolar phase to extract impurity into the apolar phase, separating the first apolar phase from the polar phase, adding a second aliquot of water to the polar phase, and contacting the polar phase with a second apolar phase, whereby the phosphoramidite partitions into the second apolar phase.
专利号:WO-2014161072-A1 优先权日:2013-04-02 标题 :Α-boryl isocyanides, boropeptides and boron heterocycles 发明人:ZAJDLIK ADAM DANIEL; YUDIN ANDREI K 权利人:UNIV TORONTO 摘要:This application pertains to α-boryl isocyanates, wherein the boronate moiety is in the form of an N-methyliminodiacetic acid (MIDA) boronate of the Formula (2) and the utility of said compounds in the synthesis of the borylamide motif (Î’-C-N amide ) in the scaffold of biologically-active boropeptides, such as bortezomib, in the enablement of heterocycle synthesis, and in multi-component reactions (MCRs), such as the Ugi and Passerini processes.
专利号:US-2012245363-A1 优先权日:2008-08-05 标题 :Process for the synthesis of agomelatine
专利号:US-2013289308-A1 优先权日:2011-01-05 标题:Process for the synthesis of agomelatine
参考文献:10.1055/s-2006-949638 摘要:Hügel H, Rix C, Fleck K. Comparison of Copper(II) Acetate Promoted N-Arylation of 5,5-Dimethyl Hydantoin and Other Imides with Triarylbismuthanes and Aryl Boronic Acids. Synlett. 2006 Sep;2006(14):2290–2. doi: 10.1055/s-2006-949638.