CAS: 1113-68-4; N-Acetyl-N-Methylacetamide

该化合物是一种多种用途的化学化合物,其应用在有机合成和制药研究中.其结构以乙酰和甲基胺功能组为主,使它成为制造更复杂的分子的宝贵中间体.该化合物在普通有机溶剂中表现出良好的溶解性,便于在各种反应条件下使用.该化合物在标准实验室条件下的稳定性确保了合成工作流程的可靠性能.研究人员赞赏其在发育peptimimicics和其他生物活性化合物方面的作用,在这些化合物中,精确的功能组别操纵至关重要.该化合物的明确界定的再活性特征进一步增强了其在受控合成转化中的实用性.

结构式图片

相似化合物

127-19-5 685-91-6 685-27-8

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

N-methyl-acetamideN-methyl-acetamide Isopropenyl acetate acetic anhydride methylamine hydr°Chloride(E)-3-phenylacrylic acid (E)-N-methyl-3-phenyl-acrylamide N-methyl-acetamideN-methyl-acetamide Acetanilid

合成工艺路线路线简述

    📜Trimethylsilyl-Essigsaeure-N-Acetyl-N-Methyl-Amid 以 甲醇 用作溶剂,化学反应生成N-甲基二乙酰胺
    参考文献:烯酮与甲硅烷基化胺或酰胺的相互作用
    标题:烯酮与甲硅烷基化胺或酰胺的相互作用
    摘要:在对乙烯酮与单或二烷基氨基硅烷的相互作用的研究中,观测到许多新的重排.当受到烯酮作用时,二烷基氨基硅烷根据所施加的条件,会生成β-甲硅烷氧基乙烯基乙酸(i)的酰胺(路线" A",方案a)或甲硅烷基乙酸的酰胺(II)(路线" B"," C").在两种情况下,均分离出中间体α-甲硅烷氧基乙烯基二烷基胺(III),可以将其重新排列以得到酰胺(II).
    Doi:10.1016/s0022-328X(00)88613-1

    海关参考信息

    专利信息


    专利号:US-8871975-B2
    优先权日:2011-01-05
    标题 :Process for the synthesis of agomelatine
    发明人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI
    权利人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI; SERVIER LAB
    摘要:Process for the industrial synthesis of the compound of formula (I)

    专利号:US-8212077-B2
    优先权日:2008-08-05
    标 题:Process for the synthesis of agomelatine
    发明人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS
    权利人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS; SERVIER LAB
    摘要:Process for the industrial synthesis of the compound of formula (I)

    专利号:US-7030230-B2
    优先权日:2002-10-25
    标题:Process of purifying phosphoramidites
    发明人:ROSS BRUCE; SONG QUANLAI
    权利人:ISIS PHARMACEUTICALS INC
    摘要:A process of purifying phosphoramidite precursors useful in inter alia synthesis of oligonucleotides comprises dissolving a crude phosphoramidite in a polar phase, adding a basic compound to the polar phase, adding a portion of water to the polar phase, contacting the polar phase with a first apolar phase to extract impurity into the apolar phase, separating the first apolar phase from the polar phase, adding a second aliquot of water to the polar phase, and contacting the polar phase with a second apolar phase, whereby the phosphoramidite partitions into the second apolar phase.

    专利号:WO-2014161072-A1
    优先权日:2013-04-02
    标题 :Α-boryl isocyanides, boropeptides and boron heterocycles
    发明人:ZAJDLIK ADAM DANIEL; YUDIN ANDREI K
    权利人:UNIV TORONTO
    摘要:This application pertains to α-boryl isocyanates, wherein the boronate moiety is in the form of an N-methyliminodiacetic acid (MIDA) boronate of the Formula (2) and the utility of said compounds in the synthesis of the borylamide motif (Î’-C-N amide ) in the scaffold of biologically-active boropeptides, such as bortezomib, in the enablement of heterocycle synthesis, and in multi-component reactions (MCRs), such as the Ugi and Passerini processes.

    专利号:US-2012245363-A1
    优先权日:2008-08-05
    标题 :Process for the synthesis of agomelatine

    专利号:US-2013289308-A1
    优先权日:2011-01-05
    标题:Process for the synthesis of agomelatine

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1055/s-2006-949638
    摘要:Hügel H, Rix C, Fleck K. Comparison of Copper(II) Acetate Promoted N-Arylation of 5,5-Dimethyl Hydantoin and Other Imides with Triarylbismuthanes and Aryl Boronic Acids. Synlett. 2006 Sep;2006(14):2290–2. doi: 10.1055/s-2006-949638.
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