CAS: 105650-23-5; 1-Methyl-6-Phenyl-1H-Imidazo[4,5-B]Pyridin-2-Amine

该化合物是一种有机化合物,其特点是复杂的环环结构,包括imidazole和pyridine环;该化合物以潜在的生物活动而闻名,特别是诱变性和致癌性,因为它是imidazo[4,5-b] 类的衍生物;该化合物一般是晶状固体,在有机溶剂中可溶解;氨基和甲基组的存在有助于其与生物系统的再活动与互动;其分子结构允许各种替代模式,这种模式能够影响其化学特性和生物影响;由于其结构特征,该化合物可能参与各种化学反应,包括电光学替代和核细胞病.该化合物的研究往往侧重于其在食品化学中的影响,特别是在烹饪过程中的肉类方面,它可以形成.

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上下游产品

CAS号125572-33-0 1-methyl-6-phen... | CAS号878996-00-0 2-amino-1-methy... | CAS号39827-54-8 2-azidobenzo[b]... | CAS号39856-98-9 2-溴苯并[b]噻吩-3-甲醛 | CAS号1097725-70-6 1-methyl-6-phen... | CAS号625-92-3 3,5-二溴吡啶 | CAS号50720-12-2 3-溴-5-甲氧基吡啶 | CAS号20826-04-4 5-溴烟酸 | CAS号152684-24-7 乙基 (5-bromopyri... | CAS号129018-59-3 1-甲基-2-硝基-6-苯基咪... | CAS号124489-20-9 N2-OH-PhIP

合成工艺路线路线简述

  • 合成目标产物 2-Amino-1-Methyl-6-Phenylimidazo[4,5-B]Pyridine 主要起始原料 1-Methyl-6-Phenyl-1H-Imidazo[4,5-B]Pyridine
  • (文献来源)合成步骤主要原料 1-Methyl-6-Phenyl-1H-Imidazo[4,5-B]Pyridine
📜3,5-二溴吡啶置于镍 四(三苯基膦)钯,硫酸,氢气,硝酸,Sodium Carbonate体系中,用 乙醇,水,N,N-二甲基甲酰胺,苯 用作溶剂,化学反应 11.5H,反应生成2-氨基-1-甲基-6-苯基咪唑[4,5-B]吡啶
参考文献:Linstroem,Stefan; Eriksson,Mikael; Grivas,Spiros,Acta Chemica Scandinavica,1993,Vol. 47,# 8,P. 805-812
标题:Linstroem,Stefan; Eriksson,Mikael; Grivas,Spiros,Acta Chemica Scandinavica,1993,Vol. 47,# 8,P. 805-812

专利信息


专利号:US-2024261416-A1
优先权日:2023-01-31
标题:Synthesis of novel cereblon e3 ligase ligands, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; XIE HAIBO; WU YUNXIANG; LIAO JUNZHUO; LI CHUNRONG; TANDON IRA; TANG HUA
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Provided herein are achiral cereblon (CRBN) ligands based on phenyl dihydrouracil that have optimal binding to CRBN without having chiral carbons. Also provided herein are the proteolysis targeting chimeras (PROTACs) comprising the CRBN ligands and a protein binder, pharmaceutical compositions containing the PROTACs, and methods of treating diseases using the PROTACs.

专利号:US-6432650-B1
优先权日:2000-01-31
标 题:Amplification of chromosomal DNA in situ
发明人：CHRISTIAN ALLEN T; COLEMAN MATTHEW A; TUCKER JAMES D
权利人:UNIV CALIFORNIA
摘要:Amplification of chromosomal DNA in situ to increase the amount of DNA associated with a chromosome or chromosome region is described. The amplification of chromosomal DNA in situ provides for the synthesis of Fluorescence in situ Hybridization (FISH) painting probes from single dissected chromosome fragments, the production of cDNA libraries from low copy mRNAs and improved in Comparative Genomic Hybridization (CGH) procedures.

专利号:CA-3222929-A1
优先权日:2021-06-18
标题:Synthesis of vinylated hydroxy esters with applicability in signal enhanced magnetic resonance imaging

专利号:JP-H1171372-A
优先权日:1997-08-26
标题 :Synthesis of 1-methyl-6-phenylimidazo(4,5-b)pyridine

专利号:JP-2000154189-A
优先权日:1998-11-18
标题 :2-alkoxycarbonylamino-1-methyl-6-phenylimidazo[4,5- b]pyridine derivative and synthesis of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine using the same derivative

专利号:JP-2000154188-A
优先权日:1998-11-18
标题:2-benzoylamino-1-methyl-6-phenylimidazo [4,5-b]pyridine derivative and synthesis of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine using the same derivative

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主要参考文献


1: Chiavarini M, Bertarelli G, Minelli L, Fabiani R. Dietary Intake of Meat Cooking-Related Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis. Nutrients. 2017 May 18;9(5). pii: E514. doi: 10.3390/nu9050514. Review.
2: Fahrer J, Kaina B. Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogens. Food Chem Toxicol. 2017 Aug;106(Pt B):583-594. doi: 10.1016/j.fct.2016.09.029. Epub 2016 Oct 6. Review. doi: 10.1016/j.addr.2016.08.011. Epub 2016 Sep 4. Review.
4: Ganesan V, Ascherman DP, Minden JS. Immunoproteomics technologies in the discovery of autoantigens in autoimmune diseases. Biomol Concepts. 2016 May 1;7(2):133-43. doi: 10.1515/bmc-2016-0007. Review. Review. doi: 10.1016/j.jplph.2014.10.021. Epub 2014 Nov 29. Review. doi: 10.1016/B978-0-12-411638-2.00009-4. Review. doi: 10.1016/j.jmr.2014.01.005. Review.

合成参考文献


摘要:
摘要:
摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 7-4, 7-5, 8-12 (1990)
摘要:
摘要:Montesano, R., H. Bartsch, E.Boyland, G. Della Porta, L. Fishbein, R. A. Griesemer, A.B. Swan, L. Tomatis, and W. Davis (eds.). Handling Chemical Carcinogens in the Laboratory: Problems of Safety. IARC Scientific Publications No. 33. Lyon, France: International Agency for Research on Cancer, 1979., p. 17
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