CAS: 952652-79-8; N-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-N-Butyryl-L-Valine

该化合物是合成Valsartan(用于治疗高血压的血管第二受体对抗者)期间观察到的一种已知的与过程有关的杂质,这种杂质产生于涉及正丙基溴或类似试剂的授粉步骤,其识别和控制对于确保最后活性药物成分的纯度和安全至关重要.Valsartan n-Propyl Impurity的分析标准对于制药方法的开发,验证和质量控制至关重要.高纯度参考材料可以进行准确的量化,支持遵守诸如ICH Q3A 和 USP等管理准则.在优化合成工艺和保持批量一致性方面对这种杂质的正确定性辅助工具.

英文名称N-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-N-Butyryl-L-Valine
中文名称(S)-N-丁酰基-N-([2'-(1H-四唑-5-基)联苯-4-基]甲基)缬氨酸
IUPAC名称N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-N-butyryl-L-valine
其它别名Valsartan N-Propyl; Valsartan N-Propyl Impurity; L-Valine, N-(1-Oxobutyl)-N-[[2'-(2H-Tetrazol-5-yl)[1,1'-Biphenyl]-4- Yl]Methyl]-; (S)-N-Butyryl-N-([2'-(1H-Tetrazole-5-yl)Biphen-4-Yl]Methyl)Valine; Valsartan N-Propyl Impurity：(S)-N-Butyryl-N-{[2'-(1-H-Tetrazole-5-yl)-Biphenyl-4-Yl]-Methyl}-Valine; N-Butyryl-N-{[2'-(1H-Tetrazole-5-yl)-Biphenyl-4-Yl]Methyl}-L-Valine; N-(1-Oxobutyl)-N-[[2'-(2H-Tetrazol-5-yl)[1,1'-Biphenyl]-4-Yl]Methyl]-; (S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)Butyramido)-3-Methylbutanoic Acid
CAS编号952652-79-8
MFCD编号:MFCD19689078
EINECS号:808-238-4
FDA UNII编号:4GS9P3LL2L
分子式:C23H27N5O3分子量:421.5
产品CID: 2005706
产品分类生物化工 → 氨基酸及其衍生物 → 其他氨基酸衍生物

C&L通报

137863-90-2 = 952652-79-8
反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Toluene; Rt; 10 H,Rt1.2 Reagents: Tributyltin Chloride,Sodium Azide Solvents: Xylene; Rt -> Reflux; 24 - 30 H,Reflux1.3 Reagents: Potassium Hydroxide Solvents: Water; 7 H,30 - 40 °C
标题:Control Method For Impurity In Synthesis Of Valsartan
参考文献:China