CAS: 84793-24-8; Ethyl (S)-2-[(S)-4-Methyl-2,5-Dioxo-3-Oxazolidinyl]-4-Phenylbutanoate

上下游产品

CAS号82717-96-2 N-[1-(S)-乙氧羰基-3... | CAS号530-62-1 N,N'-羰基二咪唑(CDI) | CAS号32315-10-9 三光气 | CAS号75-44-5 光气 | CAS号129939-63-5 (2R,3aR,6aR)-Ra... | CAS号87333-19-5 雷米普利 | CAS号82717-96-2 N-[1-(S)-乙氧羰基-3... | CAS号76420-72-9 依那普利拉 | CAS号75847-73-3 依那普利 | CAS号115729-52-7 ethyl (2S)-2-[(... | CAS号83435-67-0 盐酸地拉普利 | CAS号87679-37-6 群多普利 | CAS号852921-57-4 (2R,3aS,7aR)-1-...

Ethyl 2-(S)-{n-Ethoxycarbonyl-N-[1-(S)-(Ethoxycarbonyloxycarbonyl)-Ethyi]-Amino}-4-Phenylbutyrate置于氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,化学反应 5.0H,以64%的收率获得产物n-[1-(S)-乙氧羰基-3-苄丙基]-L-丙氨酸-N-羰甲醛
参考文献:Wo2007/132277
标题:Wo2007/132277

专利信息

专利号:US-2007225505-A1
优先权日:2003-11-25
标题 :Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate
发明人：CID PAU
权利人:CID PAU
摘要:A method for the synthesis of a compound of formula I as a mixture of enantiomers, n n n(wherein R 1 is H or an acid protective group and H + A − indicates an optional acid with which the compound of formula I may form an ammonium salt) nsaid method comprising; A) reacting a cyclohexyl aziridine with a dialkyl malonate, whereby to provide a trans-fused 3-alkylcarbonyl-octahydro-indol-2-one; B) decarbonylation at the 3-position, conversion of the ketone of the resulting trans-octahydro-indol-2-one to an optionally protected carboxylic acid group; and C) optionally removing any N-substitution if necessary.

专利号:WO-9633984-A1
优先权日:1995-04-24
标 题:N-sulfoxy anhydrides, a process for the preparation thereof and its use for the preparation of bioactive substances having ace inhibitory action
发明人：SERRA MORTES SONIA; PALOMO COLL ALBERTO; ZUPET ROK
权利人:GENESIS PARA LA INVESTIGACION; SERRA MORTES SONIA; PALOMO COLL ALBERTO; ZUPET ROK
摘要:Novel N-sulfoxy anhydrides, a process for the preparation thereof and its use for the preparation of bioactive substances having ACE inhibitory action. Novel compounds of formula (III), wherein R1 represents PhCH2-CH2- or CH3CH2-CH2- and R2 represents methyl or R3-NH-(CH2)3-CH2-, wherein R3 has the meaning of amino protective group, are disclosed. They are used as intermediates in the synthesis of ACE inhibitors, especially of enalapril and trandolapril.

专利号:US-2009069574-A1
优先权日:2005-07-05
标 题:Process for the synthesis of an ace inhibitor

专利号:US-2010286404-A1
优先权日:2006-05-12
标 题 :pharmaceutical intermediates in the synthesis of ace-inhibitors and the use thereof

专利号:US-7960558-B2
优先权日:2006-05-12
标 题:Pharmaceutical intermediate for synthesizing ACE inhibitors and the use thereof
发明人：PORCS-MAKKAY MARTA; SIMIG GYULA; MEZEI TIBOR; PANDUR ANGELA VERESSNE; LUKACS GYULA
权利人:EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
摘要:The compounds of the general Formula (I), wherein R 1 is aryl or alkyl; R 2 represents alkyl; R 3 represents alkyl or aralkyl, are valuable pharmaceutical intermediates, which can be prepared by reacting a compound of the general Formula (IV) (wherein the definitions of R 1 and R 2 are as above), with at least 2 molar equivalents of the compound of the general Formula (VI) (wherein X represents halogen or tertiary butyloxycarbonyloxy group and R 3 is as defined above). The known compounds of the general Formula (II) (wherein R 1 and R 2 are as defined above) are prepared by reacting the compounds of the general Formula (I) with thionyl chloride. The compounds of the general Formula (I) are new intermediates useful in the synthesis of pharmaceutically active ingredients, particularly in the preparation of ACE-inhibitors, e.g. enalapril, perindopril or ramipril.

专利号:CA-2614099-A1
优先权日:2005-07-05
标题 :Process for the synthesis of the ace inhibitor