专利号:US-6264962-B1 优先权日:1997-12-19 标 题:Use of cinnamic acid or of at least one of its derivatives in a cosmetic composition 发明人:BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE 权利人:OREAL 摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. n The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.
专利号:WO-2025069039-A1 优先权日:2023-09-28 标题:An in situ process for the preparation of primary amine compounds 发明人:SAMANT RAJARAM; TONGRA MANOJ 权利人:SAMANT RAJARAM; TONGRA MANOJ 摘要:An in situ process for the preparation of primary amine compounds The invention disclosed herein relates to an in situ process for the preparation of primary amine compounds. Particularly, it relates to the preparation of primary amine compounds having general Formula (I). Formula (I) wherein n is 1 to 9 and X is -S, -N- or -O. More particularly, the present invention relates to the preparation of primary amine compounds with high yield and purity which is further used as potent intermediate in the synthesis of therapeutically active isothiocyanates (ITCs).
专利号:EP-1331924-B1 优先权日:2000-10-26 标题 :Use of beta-carotene and lycopene for treating ageing symptoms via the inhibition of the expression of the metalloproteinase of type 1 of the extracellular matrix 发明人:BRETON LIONEL; BAUR MARKUS 权利人:OREAL; NESTEC SA 摘要:Intimate admixtures of at least one carotenoid having provitamin A activity and at least one carotenoid devoid of provitamin A activity are well suited for treating the undesirable cutaneous signs of skin aging, in particular the determination of the skin and/or of the mucous membranes by inhibiting the activity and/or the expression of collagenases and by increasing the synthesis of collagen.
专利号:US-7919505-B2 优先权日:2006-07-11 标题 :Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound 发明人:TING PAULINE C; LEE JOE F; FENG KUNG-I; REEDER MICHAEL R; TRZASKA SCOTT T; ZHU MAN; MAO CHEN; FILIPOV DIMITAR L; ZARKADAS DIMITRIOS N 权利人:SCHERING CORP 摘要:The present invention relates to the compound of the formula n nTo methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to polymorphs and processes of synthesis of the polymorphic forms.
专利号:US-6660283-B2 优先权日:1997-12-19 标 题 :Use of cinnamic acid, or of at least one of its derivatives in a cosmetic composition 发明人:BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE 权利人:OREAL 摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids.The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.
专利号:WO-2023075715-A1 优先权日:2021-10-26 标题 :A pharmaceutical formulation including leukotriene receptor antagonists and/or leukotriene synthesis inhibitors combined with non-steroidal anti-inflammatory drugs (nsaids) 发明人:OYTUN FARUK; CAN EFE 权利人:VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI 摘要:This invention is related to a pharmaceutical formulation including Leukotriene receptor antagonists and/or Leukotriene synthesis inhibitors combined with non-steroidal anti-inflammatory drugs (NSAIDs) and antihistamines in ocular diseases and in inflammatory and allergic diseases for systemic and topical use. The objective of this invention is to create a novel formulation to be effective as much as steroids while having significantly less side effects for long-term use in treating ocular diseases, inflammatory and allergic diseases. In other words our aim is to achieve the inhibition of pro-inflammatory mediators (prostaglandins, thromboxane, histamine and leukotrienes) as much as steroids do with a safer combination.
1: Escuder-Gilabert L, Martín-Biosca Y, Perez-Baeza M, Sagrado S, Medina- Hernández MJ. Trimeprazine is enantioselectively degraded by an activated sludge in ready biodegradability test conditions. Water Res. 2018 Sep 15;141:57-64. doi: 10.1016/j.watres.2018.05.008. Epub 2018 May 9. 1(3):e80749. doi: 10.1172/jci.insight.80749. Epub 2016 Mar 17. 3: Genois A, Haig M, Des Roches A, Sirard A, Le May S, McCuaig CC. Case report of atopic dermatitis with refractory pruritus markedly improved with the novel use of clonidine and trimeprazine. Pediatr Dermatol. 2014 Jan-Feb;31(1):76-9. doi: 10.1111/j.1525-1470.2012.01756.x. Epub 2012 Jul 2. 23(2):87-90. doi: 10.1016/j.sdentj.2011.01.004. Epub 2011 Feb 3. 5: Agrawal K, Wu HF. Drop-to-drop solvent microextraction coupled with gas chromatography/mass spectrometry for rapid determination of trimeprazine in urine and blood of rats: application to pharmacokinetic studies. Rapid Commun Mass Spectrom. 2007;21(20):3352-6. doi: 10.1002/rcm.3221. 30(6):400-2. doi: 10.1093/jat/30.6.400. 94(5):675-83. doi: 10.1079/bjn20051495. 26(5):75-80. French. 57(5):369-74. 47(1):21-8. 7(4):502-13. doi: 10.1037//1064-1297.7.4.502. 158(2):125-31. doi: 10.1006/taap.1999.8699. 45(1):3-11.
合成参考文献
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