CAS: 777-52-6; 4-Nitrophenyl Phosphorodichloridate

上下游产品

CAS号100-02-7 对硝基苯酚 | CAS号824-78-2 4-硝基苯酚钠 | CAS号28341-54-0 4-(4-硝基苯氧基)丁酸 | CAS号3871-20-3 三(4-硝基苯基)磷酸酯 | CAS号950-35-6 甲基对氧磷 | CAS号2255-19-8 dibutyl (4-nitr... | CAS号18123-87-0 butyl (4-nitrop... | CAS号189635-44-7 hexadecyl methy... | CAS号2365-54-0 2-(4-nitropheno... | CAS号311-45-5 对硫磷(乙基对硫磷) | CAS号10359-36-1 4-NITROPHENYLDI... | CAS号102185-28-4 4-氨基苯基磷酰氯 | CAS号21064-69-7 O-(对硝基苯基磷酰)胆碱

对硝基苯酚置于sodium Chloride,三氯氧磷体系中,化学反应 6.0H,以54%的收率获得产物4-硝基苯二氯化磷
参考文献:磷酰乙醇胺二酯的水解机理.分子内亲核胺参与
标题:磷酰乙醇胺二酯的水解机理.分子内亲核胺参与
摘要:在35oc的水中,已在一系列n-烷基-O-芳基磷酰基乙醇胺中检测了磷下的分子内置换反应.ph速率曲线的检查以及31 P NMR对反应产物的直接观察表明该胺具有亲核作用.观测到速率提高了10 6-10 7.通过改变p由来结构反应性的相关性ķ一个的胺和离去基团屈服值β Nuc ≃0.7和β 1克1.25-1.25并支持非耦合的协调机制.讨论了涉及胺和氧阴离子与分子间和分子内磷酸二酯和三酯的亲核反应机理.
DOI:10.1039/p29800000373

专利信息

专利号:US-4749742-A
优先权日:1985-07-18
标题 :Solid phase peptide synthesis
发明人：ELMORE DONALD T
权利人:QUEENS S UNIVERSITY OF BELFAST
摘要:A method of solid phase peptide synthesis and a reusable insoluble polymer resin having functional groups of the formula n n Resin--NHRNHCO(CH.sub.2).sub.n OH n n wherein R is an branched or straight chain alkyl or cycloalkyl group having 2 to 20 carbon atoms, an aromatic group, substituted aromatic group, heterocyclic group or substituted heterocyclic group preferably 1,4-dimethylcyclohexane, and n is an integer, preferably 3. Phosphorylation followed by reaction with a diol, preferably 1,4-bis(hydroxymethyl)benzene, affords a substrate upon which peptides may be synthesized by repeated deprotection and coupling with protected amino acids.

专利号:US-8614312-B2
优先权日:2008-02-21
标 题 :Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared
发明人：PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE
权利人:PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER II
摘要:The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:WO-2011123668-A2
优先权日:2010-03-31
标 题:Stereoselective synthesis of phosphorus containing actives

专利号:WO-2015158317-A1
优先权日:2014-04-15
标 题:Use of a l,3j5-triazin-2-yl phosphoramidate compound in the synthesis of sofosbuvir

专利号:CN-119320417-A
优先权日:2016-11-11
标 题:Efficient and scalable synthesis of nicotinoyl ribosides and reduced nicotinoyl ribosides, their modified derivatives, phosphorylated analogs, adenosine dinucleotide conjugates, and novel crystalline forms