CAS: 76924-93-1; 123I-Mibg

📜3-(Trimethylstannyl)Benzylguanidine 反应生成 Meta-Iodobenzylguanidine
参考文献:Process For The Preparation Of Radiolabeled Meta-Halobenzylguanidine
标题:Process For The Preparation Of Radiolabeled Meta-Halobenzylguanidine
摘要:本发明提供了一种无载体加入的放射性标记的间位卤代苯基胍的合成方法,其中包括将间位三烷基锡苯基胍与卤素的放射性核素源反应进行卤代锡脱基反应.本发明还提供了作为上述过程中间体的间位三烷基锡苯基胍.

专利信息

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.

专利号:WO-2022260918-A1
优先权日:2021-06-07
标 题:Composition and method for dual targeting in treatment of neuroendocrine tumors
发明人：MOUSA SHAKER; RAJABI MEHDI; KARAKUS OZLEM O
权利人:NANOPHARMACEUTICALS LLC
摘要:Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone ανβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.

专利号:US-10053423-B2
优先权日:2014-01-03
标 题:Radioiodinated compounds
发明人：DIMAGNO STEPHEN; HU BAO
权利人:NUTECH VENTURES
摘要:This disclosure relates to reagents and methods useful in the synthesis of aryl iodines, for example, in the preparation of iodine labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.

专利号:WO-2011011384-A9
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates

专利号:US-11077082-B2
优先权日:2018-04-11
标题 :Composition and method for dual targeting in treatment of neuroendocrine tumors
发明人：MOUSA SHAKER; RAJABI MEHDI; KARAKUS OZLEM O
权利人:NANOPHARMACEUTICALS LLC
摘要:Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone αvβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.

专利号:US-11351137-B2
优先权日:2018-04-11
标题 :Composition and method for dual targeting in treatment of neuroendocrine tumors
发明人：MOUSA SHAKER; RAJABI MEHDI; KARAKUS OZLEM O
权利人:NANOPHARMACEUTICALS LLC
摘要:Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone αvβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.