CAS: 733039-20-8; 5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine

相似化合物

868591-58-6 733039-21-9 1338495-23-0

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[ECHA物质

上下游产品

CAS号36082-50-5 5-溴-2,4-二氯嘧啶 | CAS号1003-03-8 环戊胺 | CAS号1013916-37-4 2-氯-8-环戊基-5-甲基-... | CAS号733038-80-7 4-[6-[[5-溴-4-(环... | CAS号733039-23-1 5-溴-N-环戊基-2-(甲基...

氯代环戊烷,4-氨基-5-溴-2-氯嘧啶置于copper Diacetate,Sodium Hydroxide体系中,用 二氯甲烷 作为反应溶剂,化学反应 10.0H,以77%的收率获得产物5-溴-2-氯-N-环戊基-4-嘧啶胺
参考文献:一种5-溴-2-氯-N-环戊基嘧啶-4-胺的制备方法
标题:一种5-溴-2-氯-N-环戊基嘧啶-4-胺的制备方法
摘要:本发明涉及药物合成领域,公开了一种5‑溴‑2‑氯‑n‑环戊基嘧啶‑4‑胺的制备方法,本发明首次以5‑溴‑2,4‑二氯嘧啶为原料,经过氨化,烷基化两步制得5‑溴‑2‑氯‑n‑环戊基嘧啶‑4‑胺,副反应少,收率,纯度高,质量稳定.没有使用环戊胺,克服了以环戊胺作为氨基化试剂时容易产生难以分离的副产物的缺点.

专利信息

专利号:US-7781583-B2
优先权日:2006-09-08
标题:Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d] pryimidin-7-ones
发明人：ERDMAN DAVID THOMAS; FLAMME CATHLIN MARIE; NELSON JADE DOUGLAS
权利人:PFIZER
摘要:The present invention provides methods of preparing substituted 2-(pyridin-2-ylamino)-pirido[2,3-d]pyrimidin-7-ones (formula 1), n nuseful in treating cell proliferative disorders, or a pharmaceutically acceptable salt thereof.

专利号:AU-2007297286-A1
优先权日:2006-09-08
标题 :Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones

专利号:US-2008125588-A1
优先权日:2006-09-08
标 题:SYNTHESIS OF 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3-d] PRYIMIDIN-7-ONES

专利号:CN-101511829-A
优先权日:2006-09-08
标 题:Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones

专利号:JP-2008094834-A
优先权日:2006-09-08
标题 :Synthesis of 2- (pyridin-2-ylamino) -pyrido [2,3-d] pyrimidin-7-ones

专利号:CA-2662768-A1
优先权日:2006-09-08
标 题 :Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones