CAS: 71522-78-6; 1,2-Bis(Tert-Butylthio)Ethane Borane

专利信息

专利号:US-2006241298-A1
优先权日:2005-04-21
标 题:Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof
发明人：MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE
权利人:MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE
摘要:Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of felbamate, including fluorofelbamate) via reduction of malonate compounds, followed by carbamoylation. Reduction of the malonate compounds is carried out using an electrophilic hydride reagent.

专利号:US-9035061-B2
优先权日:2010-07-13
标题:Process for preparing a biphenyl-2-ylcarbamic acid
发明人：COLSON PIERRE-JEAN
权利人:COLSON PIERRE-JEAN; THERAVANCE BIOPHARMA R & D IP LLC
摘要:The invention provides a process of preparing an intermediate useful in the synthesis of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and a process of preparing a crystalline freebase of the ester.

专利号:WO-2007123900-A2
优先权日:2006-04-17
标题:Enantiomers of n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine borane as intermediates in the synthesis of duloxetine

专利号:EP-1899317-A2
优先权日:2006-04-17
标 题 :Enantiomers of n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine borane as intermediates in the synthesis of duloxetine