CAS: 6836-19-7; 7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One

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3-(4-甲氧基苯甲酰基)丙酸置于一水合肼,Sodium Hydroxide体系中,用 二乙二醇 作为反应溶剂,化学反应生成 7-甲氧基-1-萘满酮
参考文献:Bcl-2抑制剂3,4-二氢萘-1(2 H)-One衍生物的设计,合成及生物学评价
标题:Bcl-2抑制剂3,4-二氢萘-1(2 H)-One衍生物的设计,合成及生物学评价
摘要:摘要设计 了一系列新的3,4-二氢萘-1(2 H)-One衍生物(6A-F),并通过claisen-Schmidt缩合反应合成.它们的结构通过NMR,Ftir和ms光谱表征.mtt法检测它们对人肿瘤细胞hela,Hepg2,K562,Thp-1,Sw1990,Mia Paca-2,Nci-H460和sk-Br-3的抗癌活性表现出明显的抗癌活性,对lo2细胞的细胞毒性为低于dox,尤其是对于 6B 和 6D .对bcl-2蛋白 6B 的抑制活性 结果表明,亲脂性3,4-二甲氧基亚苄基和3,4-二氢萘-1(2 H)-One可以与bcl-2蛋白的活性口袋结合. 图形概要
DOI:10.1007/s11164-017-2972-X

专利信息

专利号:US-7479569-B2
优先权日:2004-02-13
标题:Process for the synthesis of (7-methoxy-3,4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; GONZALEZ BLANCO ISAAC
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-8436206-B2
优先权日:2007-08-03
标 题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine
发明人：DUBUFFET THIERRY; LECOUVE JEAN-PIERRE; HERMET JEAN-PAUL
权利人:DUBUFFET THIERRY; LECOUVE JEAN-PIERRE; HERMET JEAN-PAUL; SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I) n nApplication of such process in the synthesis of agomelatine.

专利号:US-7994359-B2
优先权日:2004-02-13
标题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; BLANCO ISAAC GONZALEZ
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-7999129-B2
优先权日:2004-02-13
标 题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; BLANCO ISAAC GONZALEZ
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-9701608-B2
优先权日:2013-12-05
标题 :Process for the synthesis of 7-methoxy-naphthalene-1-carbaldehyde and application in the synthesis of agomelatine
发明人：BRIERE JEAN-FRANÇOÃ?S; LEBEUF RAPHAËL; LEVACHER VINCENT; HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB; LES LABORATORIES SERVIER
摘要:Process for the industrial synthesis of the compound of formula (I):

专利号:US-8871975-B2
优先权日:2011-01-05
标题 :Process for the synthesis of agomelatine
发明人：ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI
权利人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI; SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I)