CAS: 626-62-0; Iodocyclohexane

相似化合物

65500-78-9 89894-77-9 87621-26-9

上下游产品

CAS号19573-22-9 Cyclohexane, azido | CAS号108-93-0 环己醇 | CAS号110-83-8 环己烯 | CAS号372-46-3 氟代环己胺 | CAS号542-18-7 氯代环己烷 | CAS号110-82-7 环己烷 | CAS号108-85-0 溴代环己烷 | CAS号108-94-1 环己酮 | CAS号286-20-4 环氧环己烷 | CAS号1569-69-3 环己硫醇 | CAS号10354-56-0 3-Pyridinecarbo... | CAS号1048971-67-0 1-(环己基(异氰基)甲基磺酰... | CAS号10547-56-5 Ethyl 2-cyclohe... | CAS号103-78-6 环己基丙酮 | CAS号110-83-8 环己烯 | CAS号4292-75-5 己基环己烷 | CAS号4292-92-6 戊基环己烷 | CAS号43125-06-0 1-cyclohexyl-3-... | CAS号3289-28-9 环己甲酸乙酯 | CAS号286-20-4 环氧环己烷

📜1,1'-氧基二(环己烷)置于磷化氢,氢碘酸体系中,化学反应生成 碘环己烷
参考文献:Lacourt,Bulletin Des Societes Chimiques Belges,1927,Vol. 36,P. 348,350,352
标题:Lacourt,Bulletin Des Societes Chimiques Belges,1927,Vol. 36,P. 348,350,352

专利信息

专利号:US-9802953-B2
优先权日:2007-10-03
标 题 :Intermediates and methods for the synthesis of halichondrin B analogs
发明人：CHASE CHARLES E; ENDO ATSUSHI; FANG FRANCIS G; LI JING
权利人:EISAI R&D MAN CO LTD
摘要:Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

专利号:WO-2017082924-A1
优先权日:2015-11-13
标题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE TERRENCE R JR; HYMEL DAVID
权利人:THE US SECRETARY DEPT OF HEALTH & HUMAN SERVICES
摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:WO-2014128524-A1
优先权日:2013-02-19
标题:An improved process for preparation of an intermediate of the pyrrolidine substituted flavones
发明人：CHENNAMSETTY SUNEELMANOHARBABU; PATIL RAJENDRA; HAREL PRASHANT; HARIHARAN SIVARAMAKRISHNAN
权利人:PIRAMAL ENTPR LTD
摘要:The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)- trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or pharmaceutically acceptable salts thereof; which are inhibitors of cyclin dependant kinases (CDKs) and can be used in the treatment of proliferative disorders such as cancer. Formula (1) wherein R 1 has the meaning as indicated in the claims. The process of the present invention has advantages of higher yield and purity, lower reaction temperature, is consistent and involves the use of non toxic solvents. The process of the present invention allows efficient large-scale synthesis and purity of the product obtained is greater than 97 %.

专利号:WO-2014128523-A1
优先权日:2013-02-19
标 题 :A process for preparation of an intermediate of the pyrrolidine substituted flavones
发明人：CHENNAMSETTY SUNEELMANOHARBABU; BOKKA RAVISHANKAR; VEERAPPAN RATHINASAMI; SIVAKUMAR MEENAKSHI; HARIHARAN SIVARAMAKRISHNAN
权利人:PIRAMAL ENTPR LTD
摘要:The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)- trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or pharmaceutically acceptable salts thereof; which are inhibitors of cyclin dependant kinases (CDKs) and can be used in the treatment of proliferative disorders such as cancer. Formula (1) wherein R has the meaning as indicated in the claims. The process of the present invention has advantages of higher yield and purity, lower reaction temperature, is consistent and involves the use of non toxic solvents. The process of the present invention allows efficient large-scale synthesis and purity of the product obtained is greater than 97 %.

专利号:US-2023357286-A1
优先权日:2020-07-24
标 题:Ketone synthesis and applications
发明人：KISHI YOSHITO; UMEHARA ATSUSHI
权利人:HARVARD COLLEGE
摘要:Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).

专利号:US-2008183007-A1
优先权日:2004-10-08
标 题 :Process For the Preparation of Alkyl Phosphinic Acids
发明人：THELIN MATS
权利人:ASTRAZENECA AB
摘要:The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative by a radical initiated reaction. The invention also relates to compounds obtainable by the method of the invention.