CAS: 59467-77-5; 8-Chloro-6-(2-Chlorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine

📜7-Chloro-5-(2-Chlorophenyl)-1,3-Dihydro-2-Nitromethylene-2H-1,4-Benzodiazepine 反应生成 氯马唑仑
参考文献:Walser,A.;Fryer,R. I.
标题:Walser,A.;Fryer,R. I.

专利信息

专利号:US-8557981-B2
优先权日:2010-05-04
标题:Process for the synthesis of 4H-imidazo [1,5-a] [1,4] benzodiazepines, in particular midazolam and salts thereof
发明人：CASTELLIN ANDREA; MAGGINI MICHELE; DONNOLA PAOLA
权利人:CASTELLIN ANDREA; MAGGINI MICHELE; DONNOLA PAOLA; ITALIANA SINT SPA
摘要:The present invention refers to a process for the preparation of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular Midazolam, through an efficient and selective decarboxylation reaction of the derivative compound of the 5-aminomethyl-1-phenyl-1H-imidazole-4-carboxylic acid of formula (II) n navoiding the formation of the 6H-imidazo[1,5-a][1,4]benzodiazepines by-products and the ensuing process for the isomerization of a 4H-imidazo[1,5-a][1,4]benzodiazepine product.

专利号:US-2011275799-A1
优先权日:2010-05-04
标题:PROCESS FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-a] [1,4] BENZODIAZEPINES, IN PARTICULAR MIDAZOLAM AND SALTS THEREOF

专利号:EP-2397470-B1
优先权日:2010-05-04
标题:Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof

专利号:IT-MI20100777-A1
优先权日:2010-05-04
标 题 :PROCEDURE FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-A] [1,4] BENZODIAZEPINE, IN PARTICULAR OF MIDAZOLAM.

专利号:IL-212505-A
优先权日:2010-05-04
标题:Process for Synthesis of 4h - Imidazo [5,1– a] [4,1] Benzodiazepines, especially Midazolam and its salts

专利号:EP-2397470-A1
优先权日:2010-05-04
标题 :Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof