乙烯基乙炔置于mercury(II) Sulfate体系中,化学反应生成 4-羟基-2-丁酮 参考文献:The Effect On Attribute Prediction Of Location Uncertainty In Spatial Data 标题:The Effect On Attribute Prediction Of Location Uncertainty In Spatial Data 摘要:A Datum Is Considered Spatial If It Contains Location Information. Typically,There Is Also Attribute Information,Whose Distribution Depends On Its Location. Thus,Error In Location Information Can Lead To Error In Attribute Information,Which Is Reflected Ultimately In The Inference Drawn From The Data. We Propose A Statistical Model For Incorporating Location Error Into Spatial Data Analysis. We Investigate The Effect Of Location Error On The Spatial Lag,The Covariance Function,And Optimal Spatial Linear Prediction (That Is,Kriging). We Show That The Form Of Kriging After Adjusting For Location Error Is The Same As That Of Kriging Without Adjusting For Location Error. However,Location Error Changes Entries In The Matrix Of Explanatory Variables,The Matrix Of Co‐variances Between The Sample Sites,And The Vector Of Covariances Between The Sample Sites And The Prediction Location. We Investigate,Through Simulation,The Effect That Varying Trend,Measurement Error,Location Error,Range Of Spatial Dependence,Sample Size,And Prediction Location Have On Kriging After And Without Adjusting For Location Error. When The Location Error Is Large,Kriging After Adjusting For Location Error Performs Markedly Better Than Kriging Without Adjusting For Location Error,In Terms Of Both The Prediction Bias And The Mean Squared Prediction Error. DOI:10.1111/j.1538-4632.2002.Tb01088.X
专利号:US-2024158926-A1 优先权日:2022-11-03 标 题 :Electrochemical synthesis of hydroxyvaleric acid from levulinic acid 发明人:HOLEWINSKI ADAM; DE SOUZA LUCAS FRANCISCO WILLIAN 权利人:UNIV COLORADO REGENTS 摘要:Disclosed herein are methods of electrochemical synthesis of hydroxyvaleric acid from levulinic acid. For example, disclosed herein are methods comprising electrochemical synthesis of hydroxyvaleric acid from levulinic acid, wherein the method is conducted in an electrochemical cell wherein a working electrode is in electrochemical contact with an aqueous electrolyte and levulinic acid, wherein the method comprises applying a potential to electrochemically reduce the levulinic acid to form hydroxyvaleric acid. Also disclosed herein are methods of synthesizing gamma-valerolactone from hydroxyvaleric acid, the method comprising acid-catalyzed esterification. Also disclosed herein are methods of use of the products produced by any of the methods herein.
专利号:US-4346039-A 优先权日:1981-03-19 标 题 :Synthesis of ochratoxins 发明人:KRAUS GEORGE A 权利人:UNIV IOWA STATE RES FOUND INC 摘要:A simple, direct synthesis route is provided for Ochratoxin compounds, particularly Ochratoxin A, Ochratoxin B, and Ochratoxin C. The reaction involves treating the dimethyl ester of 2-hydroxy-4-methylbenzene-1,3-dioic acid with a deprotonating agent, followed by addition of acetaldehyde, to provide a precursor compound, which can conveniently be converted to Ochratoxins A, B or C. The synthesis route allows for the first time laboratory and industrial scale synthesis of ochratoxins A, B and C in large quantities and pure form making them available as toxins, for use as anti-toxin investigation works, and for biological activity investigations and residue studies.
专利号:US-5824801-A 优先权日:1996-01-19 标 题:Process for sterospecific synthesis of keto-enol tautomeric mixture of p nitrobenzyl (1R, 6R, 7R)-7-phenoxyacetamido-3-oxo-3-cepham-4-(R/S)-carboxylate-1-oxide and p-nitrobenzyl (1R, 6R, 7R)-7-phenoxyacteamido-3-hydroxy-3-cephem-4-carboxylate-1-oxide 发明人:GUPTA NIRANJAN LAL; SANKARAN RAMANATHAN; CHATTEJEE SUGATA; KRISHNA TUMMA HARI 权利人:LUPIN LAB LTD 摘要:A process for the stereospecific synthesis of keto-enol tautomeric mixture of p-nitrobenzyl (1R,6R,7R)-7-phenoxyacetamido-3-oxo-3-cepham-4-(R/S)-carboxylate-1-oxide and p-nitrobenzyl (1R,6R,7R)-7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate-1-oxide is described. These compounds are valuable intermediates for the synthesis of cephalosporin antibiotics e.g. cefaclor.
专利号:US-8822187-B1 优先权日:2011-04-27 标题:Polypeptides, nucleic acid molecules, and methods for synthesis of triterpenes 发明人:CHAPPELL JOE; NIEHAUS THOMAS D; OKADA SHIGERU; DEVARENNE TIMOTHY P; WATT DAVID S 权利人:CHAPPELL JOE; NIEHAUS THOMAS D; OKADA SHIGERU; DEVARENNE TIMOTHY P; WATT DAVID S; UNIV KENTUCKY RES FOUND 摘要:This application relates to the polypeptides, nucleic acid molecules, vectors, transfected cells, and methods for synthesis of triterpenes, including botryococcene.
专利号:US-4769497-A 优先权日:1986-07-04 标题:Process for the synthesis of 2,2-dialkoxy-propanes 发明人:MESSINA GIUSEPPE; MORETTI MARIO D; SANNA GAVINO; SANNA SALVATORE R; SOMA GIOVANNI 权利人:ENICHEM ANIC SPA 摘要:A new method of synthesis of a 2,2-dialkoxy-propane e.g. 2,2-dimethoxy-propane, is described through reaction of a cyclic ketal, e.g. 2,2-dimethyl-(1,3)-dioxolane, with a boric acid alkyl ester, e.g. boric acid trimethyl ester, in the presence of an acidic catalyst. The reaction may be carried out either in liquid or in vapour phase. In the latter case, heating of the thus obtained intermediate mixture to the reflux temperature should follow the catalytic step.
专利号:US-2012029226-A1 优先权日:2009-02-06 标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives 发明人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE 权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE 摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.
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合成参考文献
参考文献:10.1371/journal.pone.0021757 摘要:Meng T, Kolpe AB, Kiener TK, Chow VTK, Kwang J. Display of VP1 on the Surface of Baculovirus and Its Immunogenicity against Heterologous Human Enterovirus 71 Strains in Mice. PLoS ONE. 2011 Jul 01;6(7):e21757. doi: 10.1371/journal.pone.0021757. 参考文献:10.1074/mcp.m110.007146 摘要:Zheng YZ, Boscher C, Inder KL, Fairbank M, Loo D, Hill MM, Nabi IR, Foster LJ. Differential Impact of Caveolae and Caveolin-1 Scaffolds on The Membrane Raft Proteome. Molecular & Cellular Proteomics. 2011 Oct;10(10):M110.007146. doi: 10.1074/mcp.m110.007146. 参考文献:10.1007/s11095-011-0539-x 摘要:Paudel A, Van den Mooter G. Influence of Solvent Composition on the Miscibility and Physical Stability of Naproxen/PVP K 25 Solid Dispersions Prepared by Cosolvent Spray-Drying. Pharmaceutical Research. 2011 Jul 20;29(1):251–70. doi: 10.1007/s11095-011-0539-x. 参考文献:10.1371/journal.ppat.0010031 摘要:Zhang S, Chen Y, Potvin E, Sanschagrin F, Levesque RC, McCormack FX, Lau GW. Comparative Signature-Tagged Mutagenesis Identifies Pseudomonas Factors Conferring Resistance to the Pulmonary Collectin SP-A. PLoS Pathog. 2005 Nov 25;1(3):e31. doi: 10.1371/journal.ppat.0010031. 参考文献:10.1186/1752-0509-5-116 摘要:Imam S, Yilmaz S, Sohmen U, Gorzalski AS, Reed JL, Noguera DR, Donohue TJ. iRsp1095: A genome-scale reconstruction of the Rhodobacter sphaeroides metabolic network. BMC Systems Biology. 2011 Jul 21;5(1):116. doi: 10.1186/1752-0509-5-116.