CAS: 56651-58-2; 2-Methylbenzylisocyanate

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CAS号10166-09-3 邻甲基苯乙酰氯 | CAS号644-36-0 邻甲基苯乙酸 | CAS号7093-91-6 CHLOROMETHYL IS... | CAS号108-88-3 甲苯

📜邻甲基苯乙酰氯置于sodium Azide体系中,用 氯仿,水,丙酮 作为反应溶剂,化学反应 1.0H,反应生成 2-甲基苄基异氰酸酯
参考文献:Orally Active .Beta.-Lactam Inhibitors Of Human Leukocyte Elastase-1. Activity Of 3,3-Diethyl-2-Azetidinones
标题:Orally Active .Beta.-Lactam Inhibitors Of Human Leukocyte Elastase-1. Activity Of 3,3-Diethyl-2-Azetidinones
摘要:A Thorough Analysis Of The Mechanism Of Inhibition Of Human Leukocyte Elastase (Hle) By A Monocyclic Beta-Lactam And The Mechanism Of Beta-Lactam Hydrolysis Led To The Preparation Of Potent And Highly Stable Inhibitors Of Hle. This Work Led To The Identification Of 4-[(4-Carboxyphenyl)-Oxy]-3,3-Diethyl-1-[[(Phenylmethyl)Amino]Carbonyl]-2-Azetidinone (2) As The First Orally Active Inhibitor Of Human Leukocyte Elastase (Hle). Analogs Of 2 With Different Substituents On The Urea N Were Synthesized And Evaluated For Their Activity In Vitro Against Hle As Well As In Vivo In A Hamster Lung Hemorrhage Model. Compounds With A Methyl Or A Methoxy Group In The Para Position Of The Benzene Ring Were Very Potent In Both Assays. The Results Are Discussed On The Basis Of The Proposed Model For The Binding Of This Class Of Inhibitors To Hle And A Possible Mechanism Of Inhibition Is Presented.
DOI:10.1021/jm00099A003

专利信息

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:US-5629394-A
优先权日:1992-12-17
标 题 :Direct synthesis by living cationic polymerization of nitrogen-containing polymers
发明人：CHERADAME HERVE M; CHEN FRANK J; STANAT JON E R; NGUYEN HUNG A; TABAR BEHROOZ R
权利人:EXXON CHEMICAL PATENTS INC
摘要:A method is provided for the direct synthesis by living cationic polymerization of novel polymeric materials functionalized with desirable nitrogen-containing functional groups such as terminal azido, cyano, carbonylamino, cyanato, thiocyanato or thiocarbonylamino groups. Polymerization and functionalization occur in a substantially simultaneous manner. All necessary reactants for the functionalization are present when polymerization is initiated. The nitrogen-containing functional group is provided as a part of a molecule having a release moiety which is preferably resonance stabilized or a tertiary alkyl type and which acts to aid the nitrogen-containing species in functioning as a leaving group.

专利号:US-4906767-A
优先权日:1987-06-30
标题:Monomers with urea groups
发明人：MATHIAS LON J; KURZ DAVID W
权利人:UNIV SOUTHERN MISSISSIPPI
摘要:There is disclosed a family of new vinyl monomers capable of forming polymers by free radical polymerization. The vinyl monomer is of the formula ##STR1## wherein R 1 and R 2 are substituted or unsubstituted hydrocarbons, X is O, NH or NR 3 , and R 3 is substituted or unsubstituted hydrocarbon. n The intermediates in the synthesis of these monomers are new beta-chloroalanine ureas. The polymers are useful in film and fiber formation and display good toughness. These new vinyl monomers also form a cyclic monomer.

专利号:US-4985522-A
优先权日:1987-06-30
标题:Polymers containing pendant urea groups
发明人：MATHIAS LON J; KURZ DAVID W
权利人:UNIV SOUTHERN MISSISSIPPI
摘要:There is disclosed a family of new vinyl monomers capable of forming polymers by free radical polymerization. The vinyl monomer is of the formula ##STR1## wherein R 1 and R 2 are substituted or unsubstituted hydrocarbons, X is O, NH or NR 3 , and R 3 is substituted or unsubstituted hydrocarbon. n The intermediates in the synthesis of these monomers are new beta-chloroanaline ureas. The polymers are useful in film and fiber formation and display good toughness. These new vinyl monomers also form a cyclic monomer.

专利号:WO-9427963-A1
优先权日:1993-05-27
标 题:Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine

专利号:US-5336745-A
优先权日:1988-06-28
标题 :Terminally-substituted polymeric compositions from cationically polymerizable monomers and initiators
发明人：CHERADAME HERVE M; LUNDBERG ROBERT D; CHEN FRANK J; HABIMANA JEAN DE LA CROIS
权利人:EXXON CHEMICAL PATENTS INC
摘要:A method is provided for the direct synthesis of novel polymeric materials functionalized with desirable nitrogen-containing functional groups such as terminal azido, cyano, carbonylamino or thiocarbonylamino groups. Polymerization and functionalization occur in a substantially simultaneous manner. All necessary reactants for the functionalization are present when polymerization is initiated. The nitrogen-containing functional group is provided as a part of a molecule having a release moiety which is preferably resonance stabilized or of tertiary alkyl type and which acts to aid the nitrogen-containing species in functioning as a leaving group.