CAS: 551-08-6; 3-Butylideneisobenzofuran-1(3H)-One

相似化合物

94704-89-9 90965-68-7 17369-59-4

上下游产品

CAS号201230-82-2 carbon monoxide | CAS号79784-61-5 2'-bromovalerop... | CAS号85-44-9 苯酐 | CAS号109-52-4 正戊酸 | CAS号2082-59-9 戊酸酐 | CAS号550-37-8 2-戊酰基苯甲酸 | CAS号3431-67-2 butane,cadmium(2+) | CAS号64-18-6 甲酸 | CAS号20871-40-3 3-butylideneiso... | CAS号122654-56-2 3-butyl-2,3-dih... | CAS号76681-73-7 (3E)-3-Butylide... | CAS号72917-31-8 Z-亚丁基苯酞 | CAS号550-37-8 2-戊酰基苯甲酸

3-丁基-3-羟基-2-苯并呋喃-1-酮置于对甲苯磺酸体系中,用 甲苯 作为反应溶剂,以3.3 G的收率获得产物正丁亚基邻苯二甲酰胺
参考文献:苯酞内酯与氟康唑及其新类似物的协同作用作为限制唑类药物治疗念珠菌病的因素
标题:苯酞内酯与氟康唑及其新类似物的协同作用作为限制唑类药物治疗念珠菌病的因素
摘要:近年来,白色念珠菌和其他病原酵母菌对唑类抗真菌药物的耐药性迅速增加,是临床治疗中的一个重要问题.目前的药理学知识状况排除了唑类药物的撤回,因为尚未开发出其他活性物质可以有效替代它们.因此,抗酵母策略之一可能是依靠天然化合物和唑类药物的协同作用的疗法,限制唑类药物对抗念珠菌病的使用.体外进行的协同测定用于评估药物相互作用分数抑制浓度指数.氟康唑 (1) 和三种与芹菜植物中天然存在的合成内酯相同的协同作用-3-正丁基苯酞 (2),3-正亚丁基苯酞 (3),3-正丁基-4,5,6,7-四氢苯酞 (4)-针对白色念珠菌atcc 10231,白色念珠菌atcc 2091 和吉里蒙念珠菌kkp 3390 的性能分别与各个化合物的性能进行了比较.氟康唑 (1) 的 Mic 90 (抑制酵母生长 90% 的抑菌物质的量(以 µg/ml 为单位))测定为 5.96-6.25 µg/ml,内酯2-4
DOI:10.3390/antibiotics11111500

专利信息

专利号:US-10682335-B2
优先权日:2014-07-28
标题 :Use of butylidenephthalide (Bdph), method of using the same, and method for preparing pharmaceutical composition containing the same
发明人：SU HONG-LIN; CHANG CHIA-YU; HWANG SHIAW-MIN; Lu huai-en; HARN HORNG-JYH; LIN SHINN-ZONG; LAI PING-SHAN
权利人:EVERFRONT BIOTECH INC
摘要:The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the β-amyloid protein (Aβ) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of Aβ in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered. Furthermore, the method for preparing a pharmaceutical composition containing Bdph comprises preparing the pharmaceutical composition through an organic synthesis reaction, wherein the Bdph is coated with a polymeric material such as F127 by covalent bonding of the polymeric material with the Bdph, thereby achieving the effect of reducing the cytotoxicity of the pharmaceutical composition for an organism.

专利号:US-12403116-B2
优先权日:2022-03-04
标 题:Hydroxypentyl benzoic acid diester compound, and preparation method and pharmaceutical application thereof
发明人：SUN XIAOBO; TIAN YU; SUN XIAO
权利人:CHINESE ACADEMY OF MEDICAL SCIENCES INST OF MEDICINAL PLANT DEVELOPMENT
摘要:Disclosed are a hydroxypentyl benzoic acid diester compound, a method preparing the same, and an application of the same. This application uses a combination principle, on the one hand, the medicine concentration of butylphthalide in cerebral vessels is improved through a function of promoting the medicine to penetrate through a blood-brain barrier of dexborneol, and a multi-target multi-channel synergistic brain protection effect of the medicine is exerted; on the other hand, the treatment effect of dexborneol on cerebral ischemia is exerted. Anti-cerebral ischemia in-vivo pharmacodynamic activity evaluation is carried out on the synthesized compound, a high-activity candidate medicine is obtained, and industrial production can be achieved through the synthesis method.

专利号:US-10543191-B2
优先权日:2017-01-25
标题:Use of butylidenephthalide (Bdph), method of using the same, and method for preparing pharmaceutical composition containing the same
发明人：SU HONG-LIN; CHANG CHIA-YU; HWANG SHIAW-MIN; Lu huai-en; HARN HORNG-JYH; LIN SHINN-ZONG; LAI PING-SHAN
权利人:EJIA BIOTECHNOLOGY CO LTD
摘要:The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the β-amyloid protein (Aβ) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of Aβ in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered. Furthermore, the method for preparing a pharmaceutical composition containing Bdph comprises preparing the pharmaceutical composition through an organic synthesis reaction, wherein the Bdph is coated with a polymeric material such as F127 by covalent bonding of the polymeric material with the Bdph, thereby achieving the effect of reducing the cytotoxicity of the pharmaceutical composition for an organism.

专利号:US-7348034-B2
优先权日:2005-03-07
标题 :Plant based formulations for improving skin moisture, texture, and appearance
发明人：MURRAY MARY A; CRAWFORD AARON W; FAST DAVID J; DONG DORA; HUANG MICHAEL; CONNOR LYNNE MARIE
权利人:ACCESS BUSINESS GROUP INT LLC
摘要:The present invention relates to formulations of ingredients that are useful for improving the appearance, texture and/or moisture of skin. In particular, the formulations of the present invention stimulate collagen, elastin, and lipid synthesis and/or inhibit or minimize the loss of collagen, elastin, and lipids in the skin. Additionally, the formulations of the present invention inhibit matrix metalloproteases, such as MMP-1, MMP-9, collagenase, or elastase.

专利号:CN-217511828-U
优先权日:2022-04-21
标题:A kind of reactor for 3-butylidenephthalide synthesis

专利号:CN-111196794-A
优先权日:2020-01-17
标题:Synthesis method of food additive butylidene phthalide and its application in seasoning