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醋酸叔丁酯置于copper(Ll) Bromide体系中,用 乙酸乙酯 作为反应溶剂,化学反应生成 溴乙酸叔丁酯
参考文献:吖啶橙半(氯化锌)盐作为路易斯酸-光氧化还原杂化催化剂用于反应生成 α-羰基自由基
标题:吖啶橙半(氯化锌)盐作为路易斯酸-光氧化还原杂化催化剂用于反应生成 α-羰基自由基
摘要:据报道,一种易于获得的有机-无机杂化催化剂用于α-卤代羰基化合物的还原断裂.稳健的杂化催化剂是 Zncl 2 Lewis 酸和吖啶橙作为光活性有机染料的自稳定组合.已经使用光物理和电化学实验详细研究了这种混合催化剂的机械特性.一项系统的研究使我们能够发现合适的路易斯酸以有效地稳定α-卤代羰基化合物,从而降低标准有机染料范围内的还原电位.该策略通过引导光氧化还原循环通过氧化猝灭途径解决了脱卤氢化或烷基自由基同源偶联等问题.光活性有机染料和路易斯酸对应物之间的协同作用通过有效和受控地反应生成烷基自由基,使功能化与广泛的偶联伙伴成为可能,并作为昂贵的后过渡金属基光催化剂的合适替代品.为了证明这种协同催化体系的应用潜力,研究了四种不同的α-羰基溴的合成转化,具有广泛的底物范围.
DOI:10.1002/adsc.202101053

专利信息

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-6207858-B1
优先权日:1999-03-03
标 题 :Regioselective synthesis of DTPA derivatives
发明人：CHINN PAUL; GYORKOS ALBERT; LABARRE MICHAEL J; RUHL STEVE; RYSKAMP THOMAS
权利人:IDEC PHARMA CORP
摘要:The present invention provides a process for high yield regioselective synthesis of DTPA derivatives that eliminates the need for ion exchange chromotographic separation of intermediates. Moreover, as this process yields a single regioisomer of the chelate, it provides for the regiospecific synthesis of desired chelates useful as radiolabeling agents.

专利号:US-10011580-B2
优先权日:2016-04-21
标题:Diastereoselective synthesis of (±)-epianastrephin, (±)-anastrephin and analogs thereof
发明人：WALSE SPENCER S; KUZMICH DANIEL
权利人:US AGRICULTURE
摘要:A process for the synthesis of trans-fused γ-lactones having Formula (IV) from substituted cyclic ketones having Formula (I). A diastereoselective synthesis of (±)-epianastrephin (1) (wherein: R 1 is ethenyl, R 2 and R 3 is methyl, and n is 1), (±)-anastrephin (2) (wherein: R 2 is ethenyl, R 1 and R 3 is methyl and n is 1), and analogs thereof (wherein: R 1 is H, C 1-5 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, R 2 is H, C 1-5 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, R 1 and R 2 together with the carbon atom they are attached form a C 3-6 cycloalkyl ring, R 3 is C 1-5 alkyl and n is 0-2):

专利号:WO-0058264-A1
优先权日:1999-03-26
标 题:Method for the synthesis of non-symmetrical dtpa compounds
发明人：ACHILEFU SAMUEL I; SRINIVASAN ANANTHACHARI
权利人:MALLINCKRODT INC; ACHILEFU SAMUEL I; SRINIVASAN ANANTHACHARI
摘要:The synthesis of compounds of formula (XIV) wherein each R4 is an alkyl group having 1 to 15 carbon atoms, and R6 is a linking moiety having 1 to 10 carbon atoms, is disclosed. These compounds are useful intermediates in the synthesis of compounds of formula (X). These compounds are useful in the preparation of nuclear pharmaceuticals such as those used for tumor imaging or tumor therapy.

专利号:WO-0102339-A1
优先权日:1999-07-01
标题 :Versatile method for the synthesis of iso-dtpa
发明人：ACHILEFU SAMUEL I
权利人:MALLINCKRODT INC; ACHILEFU SAMUEL I
摘要:The synthesis of compounds of formula (XII) is disclosed. These compounds are useful intermediates in the synthesis of compounds of formulae (XI) and (X). These compounds are useful in the preparation of nuclear pharmaceuticals such as those used for tumor imaging or tumor therapy.