CAS: 487-21-8; Pteridine-2,4(1H,3H)-Dione

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CAS号6164-78-9 2,3-吡嗪二甲酰胺 | CAS号2236-60-4 2-氨基-4-羟基蝶啶 | CAS号3240-72-0 5,6-氨基-2,4(1H,3... | CAS号517-21-5 乙二醛亚硫酸氢钠水合物 | CAS号5424-01-1 3-氨基吡嗪-2-羧酸 | CAS号57-13-6 尿素 | CAS号1127-93-1 2,4-Pteridinediamine | CAS号142645-43-0 2-pivaloylamino... | CAS号7647-01-0 盐酸 | CAS号5049-61-6 氨基吡嗪 | CAS号98138-05-7 2,4-二氯蝶啶 | CAS号20737-42-2 3-羟基-2-吡嗪甲酸 | CAS号5424-01-1 3-氨基吡嗪-2-羧酸 | CAS号50255-86-2 trimethyl-(2-tr...

📜2-氨基-4-羟基蝶啶置于高氯酸体系中,化学反应 0.42H,以46%的收率获得产物2,4-二羟基蝶啶
参考文献:Lumazine 和黄嘌呤的一步合成:Lumazine 和高氯酸的第一个共晶体,具有独特的一水合氢离子 (H5O2+) 介导的 Lumazine 二聚体超分子组装
标题:Lumazine 和黄嘌呤的一步合成:Lumazine 和高氯酸的第一个共晶体,具有独特的一水合氢离子 (H5O2+) 介导的 Lumazine 二聚体超分子组装
摘要:高氯酸介导的一步合成 Lumazine 衍生物从蝶呤和黄嘌呤从鸟嘌呤合成.然而,蝶呤的 2-新戊酰氨基衍生物经过新戊酰氨基的简单水解,产生游离蝶呤化合物,但未获得 2-氧代衍生物,即 Lumazine 化合物.通过 H5O2+ 的独特氢键桥接 Lumazine 的两个氢键二聚体,与高氯酸水溶液形成共晶 21,构建了一种新型超分子组装体.相比之下,N2-Pivaloyl-6-Bromo-5-Deazapterin 被简单地水解形成质子化的 Deazapterin 22,它形成独特的六元环状氢键结构,导致反应生成聚合物超分子组装.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2007)
DOI:10.1002/ejoc.200700271

专利信息

专利号:US-9605019-B2
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids
发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.

专利号:US-9695211-B2
优先权日:2008-12-02
标题 :Method for the synthesis of phosphorus atom modified nucleic acids
发明人：WADA TAKESHI; SHIMIZU MAMORU
权利人:WAVE LIFE SCIENCES JAPAN INC
摘要:Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phosphonate moiety with a nucleoside/nucleotide.

专利号:US-12428442-B2
优先权日:2017-06-21
标题 :Compounds, compositions and methods for synthesis
发明人：BUTLER DAVID CHARLES DONNELL; HENCKEN CHRISTOPHER P; IWAMOTO NAOKI; KANDASAMY PACHAMUTHU; LANAO ALVARO ANDRES; LU GENLIANG; SHIMIZU MAMORU; DIVAKARAMENON SETHUMADHAVAN; VARGEESE CHANDRA; BOMMINENI GOPAL REDDY; MARAPPAN SUBRAMANIAN
权利人:WAVE LIFE SCIENCES LTD
摘要:The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

专利号:WO-0044727-B1
优先权日:1999-01-30
标题:Inhibitors for the biosynthesis of vitamin b2 and method for producing same
发明人：BACHER ADELBERT; CUSHMAN MARK S; KIS KLAUS; MIHALIC JEFFREY T; YANG DONGLAI; MAVANDADI FARAHNAZ; KUGELBREY KARL B
权利人:BACHER ADELBERT; CUSHMAN MARK S; KIS KLAUS; MIHALIC JEFFREY T; YANG DONGLAI; MAVANDADI FARAHNAZ; KUGELBREY KARL B
摘要:The invention relates to a class of inhibitors of general formula (I, II, III and IV) for the biosynthesis of vitamin B2. The invention also relates to a method for producing the same. The inhibitors are effective for inhibiting lumazine synthesis and/or riboflavin synthesis. They can be used as active agents in herbicides, fungicides or bactericides.

专利号:US-2018222936-A1
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids

专利号:US-11975061-B2
优先权日:2018-09-05
标题:Protective immunity enhanced Salmonella vaccine (PIESV) against Brucella spp
发明人：CURTISS III ROY
权利人:UNIV FLORIDA
摘要:Bacterial pathogens have evolved means to succeed as pathogens by infecting without recognition by receptors triggering innate immunity, by suppressing induction of immunity and by inducing immune responses to antigens that confer no protectives immunity. Embodiments described herein circumvent these abilities in Salmonella so as to provide a vector system that induces maximal protective immune responses. Another major problem in using live attenuated bacterial vaccine vectors is the accumulation of attenuating mutations that confer a virulence and safety but which decrease the ability of the vaccine to invade cells in the MALT to colonize and persist in internal effector lymphoid tissues. The embodiments disclosed herein solve this problem in multiple ways by using regulated delayed in vivo shut off of virulence genes, regulated delayed synthesis of recombinant protective antigens and regulated delayed lysis in vivo to confer biological containment with no persistence of vaccine cells and no survival if excreted.