CAS: 480-23-9; Orobol

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CAS号552-58-9 圣草酚 | CAS号446-72-0 染料木素 | CAS号66026-81-1 8-(β-D-glucopyr... | CAS号118949-94-3 6,8-di-C-β-D-gl...

📜染料木素置于维生素 C体系中,用 二甲基亚砜 作为反应溶剂,化学反应 1.5H,反应生成 3',4',5,7-四羟基异黄酮
参考文献:两种重组大肠杆菌菌株生物转化染料木黄酮生产甲氧基异黄酮及其抗黑色素瘤活性
标题:两种重组大肠杆菌菌株生物转化染料木黄酮生产甲氧基异黄酮及其抗黑色素瘤活性
摘要:使用表达来自巨大芽孢杆菌的酪氨酸酶的重组大肠杆菌通过连续 3'-羟基化,然后使用表达来自 Streptomyces Peucetius 的 O-甲基转移酶的另一种重组大肠杆菌进行甲基化,对大豆异黄酮染料木黄酮进行生物转化.结果表明,生物转化产生了两种代谢物,根据它们的质量和核,分别鉴定为 5,7,4'-三羟基-3'-甲氧基异黄酮和 5,7,3'-三羟基-4'-甲氧基异黄酮.磁共振波谱数据.5,7,4'-三羟基-3'-甲氧基异黄酮对小鼠 B16 黑色素瘤细胞显示出有效的抗增殖活性,Ic50 值为 68.8 μm.相比之下,即使在 350 μm 浓度下,该化合物对小鼠正常成纤维细胞也没有表现出任何细胞毒性.
DOI:10.3390/molecules22010087

专利信息

专利号:US-10030003-B2
优先权日:2014-09-10
标 题:Synthesis of isoflavanes and intermediates thereof
发明人：BELIAEV NIKOLAI; SHAFRAN YURI
权利人:SYSTEM BIOLOGIE AG
摘要:Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.

专利号:US-8969596-B2
优先权日:2008-08-14
标题:Synthesis of equol
发明人：STEFFAN BERT
权利人:STEFFAN BERT
摘要:Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:US-2012094336-A1
优先权日:2008-08-14
标题:Synthesis of equol

专利号:CA-2960437-A1
优先权日:2014-09-10
标 题 :Synthesis of isoflavanes and intermediates thereof

专利号:WO-2006053688-A1
优先权日:2004-11-17
标 题:Cosmetic and dermatological preparations for the treatment of mature skin
发明人：DOERING THOMAS
权利人:HENKEL KGAA; DOERING THOMAS
摘要:The invention relates to topical cosmetic or dermatological compositions for the treatment of mature or intrinsically or extrinsically aged skin, in particular, for anti-wrinkle treatment, containing a combination of at least two selected peptides in a suitable cosmetic or dermatological vehicle, which have an effect at differing points of the process of collagen and/or fibronectin synthesis.