CAS: 4494-18-2; Isoquinoline-1-Carbaldehyde

该化合物是一种环流芳烃化合物,在等离子线骨架的1位置上形成一个气态组.这种甲醛衍生物在有机合成中很有价值,特别是作为制药,农用化学品和协调化学的多用途构件.它的硬性双环结构和反应性碳基组能够选择性地发挥作用,便利复杂的环环环框架的编制.该化合物在标准条件下表现出稳定性,确保合成应用的可靠处理.它的效用扩大到作为丁金刚石,催化剂和生物活性分子的前体,使其成为医药和材料化学研究的关键中间.高品位可以满足严格的实验要求.

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合成工艺路线路线简述

  • 合成目标产物 Isoquinoline-1-Carbaldehyde 主要起始原料 1-Methylisoquinoline
  • (文献来源)合成步骤主要原料 1-Methylisoquinoline
📜1-甲基-3,4-二氢异喹啉置于1,4-二氧六环,Selenium(Iv) Oxide,镍体系中,化学反应生成 异喹啉-1-甲醛
参考文献:Condensation Reactions Of Isoquinaldaldehyde
标题:Condensation Reactions Of Isoquinaldaldehyde
摘要:
DOI:10.1021/ja01262A058

海关参考信息

专利信息


专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人:HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-7612106-B2
优先权日:2004-12-23
标题 :Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
发明人:BOATMAN P DOUGLAS; SCHRADER THOMAS O; SEMPLE GRAEME; SKINNER PHILIP J; JUNG JAE-KYU
权利人:ARENA PHARM INC
摘要:The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. n nAlso provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

专利号:CN-107778238-A
优先权日:2016-08-29
标 题 :A new method for the synthesis of 3,4-dihydroisoquinolin-1-one and isoindoline-1-one derivatives

专利号:CN-117586170-B
优先权日:2024-01-19
标题 :Synthesis method of indole acyl derivative and isoquinoline carboxylic acid derivative

专利号:CN-117209395-A
优先权日:2023-09-14
标 题 :Synthesis method and anti-cancer activity of drugs selectively targeting proliferating cell nuclear antigen

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✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1055/s-0037-1609911
摘要:Yang C, Xia W, Jia W, Jian Y, Huang B. Photoredox-Catalyzed Decarboxylative C–H Acylation of Heteroarenes. Synlett. 2018 Jul 23;29(14):1881–6. doi: 10.1055/s-0037-1609911.
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