CAS: 4160-77-4; 3,5-Dimethylpyrimidine-2,4(1H,3H)-Dione

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CAS号84941-50-4 1,6-dihydro-1,5... | CAS号65-71-4 胸腺嘧啶 | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号25902-91-4 4(1H)-Pyrimidin... | CAS号82387-33-5 methyl (Z)-2-me... | CAS号82387-32-4 methyl (E)-2-me... | CAS号708-52-1 1,5-dimethyl-2,... | CAS号186581-53-3 重氮甲烷

📜1,6-Dihydro-1,5-Dimethyl-2-(Methylthio)-6-Oxopyrimidine置于盐酸体系中,化学反应 8.0H,以93%的收率获得产物3,5-二甲尿嘧啶
参考文献:用黄素供体和氧杂环丁烷受体修饰的dna发夹研究dna中过量电子转移的途径.
标题:用黄素供体和氧杂环丁烷受体修饰的dna发夹研究dna中过量电子转移的途径.
摘要:氧杂环丁烷是一种潜在的中间体,在特殊的修复酶(6-4 Dna光解酶)修复(6-4)dna损伤时会通过酶促形成.这些酶使用还原的和去质子化的黄素通过单电子给体切割氧杂环丁烷.在本文中,我们报道了dna发夹模型化合物的合成,该化合物包含黄素作为发夹头,并且在发夹的茎结构中包含两种不同的氧杂环丁烷.数据表明,即使在17 A的距离上,电子也能通过双链体移动.用n2O捕获移动的电子的尝试并未显示出裂解效率的降低,这表明电子移动通过双链体而不是通过溶液.电子转移取决于序列.在富含gc的dna发夹中,效率降低了2倍.
DOI:10.1002/chem.200600074

专利信息

专利号:US-2002040032-A1
优先权日:2000-07-07
标 题:Methods for stimulation of synthesis of synaptophysin in the central nervous system
发明人：GLASKY MICHELLE S; LAHIRI DEBOMOY K; FARLOW MARTIN R
摘要:A method of increasing the synthesis and/or secretion of synaptophysin comprises administering to a patient with a neurological disease or a patient at risk of developing a neurological disease an effective quantity of a purine derivative or analogue, a tetrahydroindolone derivative or analogue, or a pyrimidine derivative or analogue. If the compound is a purine derivative, the purine moiety can be guanine or hypoxanthine. The neurological disease can be a neurodegenerative disease such as Alzheimer's disease or a neurodevelopmental disorder such as Down's syndrome. Typically, the compound can pass through the blood-brain barrier. The purine moiety can be hypoxanthine or guanine. A particularly preferred purine derivative is N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide.

专利号:US-8541569-B2
优先权日:2008-09-06
标题:Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:The present invention provides building blocks and methods for synthesizing very pure RNA in a form that can efficiently be modified at the 3′ end. Reverse RNA monomer phosphoramidites have been developed for RNA synthesis in 5′→3′ direction, leading to very clean oligo synthesis that allows for the introduction of various modifications at the 3′-end cleanly and efficiently. Higher coupling efficiency per step have been observed during automated oligo synthesis with the reverse RNA amidites disclosed herein, resulting in a greater ability to achieve higher purity and produce very long oligonucleotides. The use of the reverse RNA phosphoramidites in the synthetic process of this invention leads to oligonucleotides free of N+1 species.

专利号:US-2004116453-A1
优先权日:2001-07-17
标 题 :Synthesis and methods of use pyrimidine analogues and derivatives
发明人：FICK DAVID B; FOREMAN MARK M; GLASKY ALVIN J
摘要:A pyrimidine derivative or analogue comprises an amino-substituted six-membered heterocyclic moiety, moiety A, linked through a linker L to a moiety B, where B is a carboxylic acid, a carboxylic acid ester, or a moiety of the structure N(Y 1 )-D, where Y 1 can be one of a variety of substituents, including hydrogen or alkyl, and D is a moiety that enhances the pharmacological effects, promotes absorption, or promotes blood-brain barrier penetration of the derivative or analogue. The moiety A can have two or three nitrogen atoms in the ring; typically, the moiety A is a pyrimidine moiety, with two nitrogen atoms in the ring. The moiety B can be one of a variety of moieties, including moieties having nootropic activity or other biological or physiological activity.

专利号:US-5717083-A
优先权日:1994-02-23
标题 :Phosphoramidate and phosphorothiomidate oligomeric compounds
发明人：COOK PHILLIP DAN; ACEVEDO OSCAR; HEBERT NORMAND
权利人:ISIS PHARMACEUTICALS INC
摘要:PCT No. PCT/US95/02267 Sec. 371 Date Aug. 19, 1996 Sec. 102(e) Date Aug. 19, 1996 PCT Filed Feb. 23, 1995 PCT Pub. No. WO95/23160 PCT Pub. Date Aug. 31, 1995Compounds are provided having structure (I), wherein the L groups are backbone segments, the Y and T groups are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds and wherein the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidation step or during a coupling step. (I)

专利号:WO-2010096201-A2
优先权日:2009-02-22
标 题 :Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeutics, diagnostics, g- tetrad forming oligonucleotides and aptamers

专利号:WO-0204451-A2
优先权日:2000-07-07
标 题:Methods for stimulation of synthesis of synaptophysin in the central nervous system