CAS: 37949-03-4; 8,9-Dihydro-5H-Benzo[7]Annulen-7(6H)-One

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1,2-双(2-溴乙基)苯置于乙醚,硫酸,苯基锂,N-甲基苯胺体系中,化学反应生成 5,6,8,9-四氢-苯并环庚烯-7-酮
参考文献:Azabenzazulenes. I. 1-Azadibenz[b,F]Azulene
标题:Azabenzazulenes. I. 1-Azadibenz[b,F]Azulene
摘要:
DOI:10.1021/ja01609A061

专利信息

专利号:US-4992574-A
优先权日:1987-11-06
标题:Benzocycloheptene derivatives
发明人：KLAUS MICHAEL; MOHR PETER
权利人:HOFFMANN LA ROCHE
摘要:A compound of the formula ##STR1## wherein R 1 is hydroxy, lower-alkoxy, amino, mono- or di-lower-alkylamino; n R 2 is hydrogen, alkyl, akoxy or halogen; n R 3 , R 4 , R 5 , R 6 , R 11 and R 12 independently are hydrogen or lower-alkyl; n R 3 and R 5 taken together are methylene or hydroxymethylene; n R 7 , R 8 , R 9 and R 10 independently are hydrogen or lower-alkyl; n R 11 and R 12 taken together are oxo or spiro-cyclo-lower alkyl; or R 11 is hydrogen and R 12 is hydroxy or acetoxy; and one of the residues R 13 and R 14 is hydrogen and the other is lower-alkyl or trifluoromethyl, as well as physiologically compatible salts of carboxylic acids of formula I, which can be used as medicaments, especially for the treatment of neoplasms, acne and psoriasis, are described. The compounds of the invention can be prepared by the synthesis of the C(R 13 )â•?C(R 14 ) double bond according to Wittig from a corresponding bicyclic component and a corresponding monocyclic component and optional subsequent transformation of functional grous.