2-苯乙胺盐酸盐置于硝酸体系中,化学反应生成4-硝基苯乙胺盐酸盐 参考文献:Elimination Reactions Of N-[2-(P-Nitrophenyl)Ethyl]Alkylammonium Ions By An E1Cb Mechanism 标题:Elimination Reactions Of N-[2-(P-Nitrophenyl)Ethyl]Alkylammonium Ions By An E1Cb Mechanism 摘要: Doi:10.1021/ja00340A021
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-2003082830-A1 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:WO-0006525-A9 优先权日:1998-07-25 标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:WO-0006525-A2 优先权日:1998-07-25 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:US-7982049-B2 优先权日:2001-10-30 标 题:α-form or β-form crystal of acetanilide derivative 发明人:KAWAZOE SOUICHIROU; SAKAMOTO KENICHIROU; AWAMURA YUJI; MARUYAMA TATSUYA; SUZUKI TAKAYUKI; ONDA KENICHI; TAKASU TOSHIYUKI 权利人:ASTELLAS PHARMA INC 摘要:To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide. The α-form crystal does not exhibit hygroscopicity and has stability such that it can be used as a medicine, and is useful for mass synthesis in the industrial production. The β-form crystal does not relatively exhibit hygroscopicity and is also useful as a production intermediate of the α-form crystal.
专利号:US-6448443-B1 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products