CAS: 284028-89-3; 2-(4-(Trifluoromethyl)Phenyl)-3,5,7,8-Tetrahydro-4H-Thiopyrano[4,3-D]Pyrimidin-4-One
该化合物是一个小分子抑制器,主要以其在调制Wnt信号路径中的作用而闻名;该化合物由于能够抑制气酶酶酶的活动,在癌症研究领域引起了人们的注意,这些酶酶是Wnt信号级中的一个关键角色,它参与了对-Cattinin的管制;通过破坏这一路径,XAV-939有可能抑制某些依赖Wnt信号的癌症细胞的扩散,这些细胞的生长和生存.除了其抗癌特性外, XAV-939还因其对干细胞差异和组织再生的影响进行了研究;该化合物的特点是化学结构,其中包括有助于其生物活动的具体功能组;与许多实验性化合物一样,正在进行进一步研究,以充分阐明其行动,治疗潜力和任何相关副作用的机制.
- 英文名称2-(4-(Trifluoromethyl)Phenyl)-3,5,7,8-Tetrahydro-4H-Thiopyrano[4,3-D]Pyrimidin-4-One
- 中文名称3,5,7,8-四氢-2-[4-(三氟甲基)苯基]-4H-噻喃并[4,3-d]嘧啶-4-酮
- IUPAC名称2-(4-(trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one
- 其它别名2-(4-(Trifluoromethyl)Phenyl)-3,5,7,8-Tetrahydro-4H-Thiopyrano[4,3-D]Pyrimidin-4-One; 2-[4-(Trifluoromethyl)Phenyl]-7,8-Dihydro-5H-Thiopyrano[4,3-D]Pyrimidin-4-Ol; H
- CAS编号284028-89-3
- MFCD编号:MFCD16879017
- EINECS号:687-302-1
- FDA UNII编号:G2MY39VR77
- 分子式:C14H11F3N2OS分子量:312.32
- 产品CID: 1264250
- 产品分类生物化工 → 抑制剂 → 干细胞及Wnt信号通路（Stem Cells 和 Wnt） → Wnt/β-连环蛋白抑制剂
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2903399090-其他无环烃卤化衍生物
2930909099-其他有机硫化合物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2021353681-A1
优先权日:2020-05-13
标 题 :Use of tnks inhibitors for regeneration of cartilage
发明人：KIM JIN-HONG; KIM SUKYEONG; HAN SANGBIN; CHO YONGSIK
权利人:SEOUL NAT UNIV R&DB FOUNDATION
摘要:The present disclosure relates to a method of treating arthritis by targeting Tankyrase. The methods according to the present disclosure can be advantageously used for regeneration of cartilage tissue and for treating osteoarthritis by maximizing the matrix synthesis in cartilage by inhibition of Tankyrase and regulation of other proteins related therewith.
专利号:WO-2022191130-A1
优先权日:2021-03-08
标 题:Method for proliferating cardiomyocytes, method for producing cardiomyocytes, and cardiomyocyte proliferating agent
发明人：YAMASHITA JUN; YOSHIOKA MIKI
权利人:UNIV KYOTO
摘要:Provided are a method for proliferating cardiomyocytes, a method for producing cardiomyocytes, and a cardiomyocyte proliferating agent capable of contributing to cardiac regenerative medicine, that make it possible to induce proliferation of human cardiomyocytes by a drug. The method for proliferating cardiomyocytes, method for producing cardiomyocytes, and cardiomyocyte proliferating agent, including a step for culturing cardiomyocytes in the presence of one or more compounds selected from the group consisting of ALK inhibitors, cytochrome P450 omega hydroxylase inhibitors, and fatty acid synthesis inhibitors
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Chugh RM, Bhanja P, Zitter R, Gunewardena S, Badkul R, Saha S. Modulation of β-Catenin promotes WNT expression in macrophages and mitigates intestinal injury. Cell Commun Signal. 2025 Feb 11;23(1):78. doi: 10.1186/s12964-025-02065-7.
2: Sun T, Ma D, Song Y, Hu J, Yang Z, Wang X, Zhang J. Effects of 0.01 mM strontium on human periodontal ligament stem cell osteogenic differentiation via the Wnt/β-catenin signaling pathway. J Int Med Res. 2025 Feb;53(2):3000605251315024. doi: 10.1177/03000605251315024.
3: Chen Y, Shi H, Dong Y, Cui W. LncRNA MSTO2P affects the proliferation, invasion and migration of non-small cell lung cancer by regulating the Wnt/β-catenin pathway. Discov Oncol. 2025 Feb 10;16(1):150. doi: 10.1007/s12672-025-01920-w.
合成参考文献
参考文献:10.1002/jnr.23415
摘要:Chen J, Li J, Miao Z, Xu X, Liu CF. XAV939, a small molecular inhibitor, provides neuroprotective effects on oligodentrocytes. J Neurosci Res. 2014 Oct;92(10):1252–8. doi: 10.1002/jnr.23415.
参考文献:10.1016/j.celrep.2015.09.014
摘要:Wang W, Li N, Li X, Tran M, Han X, Chen J. Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins. Cell Reports. 2015 Oct;13(3):524–32. doi: 10.1016/j.celrep.2015.09.014.
参考文献:10.1007/164_2021_525
摘要:De Palma A, Nalesso G. WNT Signalling in Osteoarthritis and Its Pharmacological Targeting. Handb Exp Pharmacol. 2021;269():337–56. doi: 10.1007/164_2021_525.
参考文献:10.1186/s13287-021-02660-8
摘要:Xin T, Li Q, Bai R, Zhang T, Zhou Y, Zhang Y, Han B, Yang R. A novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/β-catenin signaling pathway. Stem Cell Research & Therapy. 2021 Dec 04;12(1):595. doi: 10.1186/s13287-021-02660-8.
参考文献:10.1186/s13287-021-02677-z
摘要:Wu H, Xie X, Sun M, Chen M, Tao X, Fang X, Meng X, Wei W, Yu M. Modification of mesenchymal stem cells by HMGB1 promotes the activity of Cav3.2 T-type calcium channel via PKA/β-catenin/γ-cystathionase pathway. Stem Cell Research & Therapy. 2022 Jan 10;13(1):4. doi: 10.1186/s13287-021-02677-z.
📝 需求与反馈
尽可能描述清楚需求与问题信息
