CAS: 27115-49-7; 2-(3-Methylbenzamido)Acetic Acid

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CAS号56-40-6 甘氨酸 | CAS号1711-06-4 间甲基苯甲酰氯 | CAS号42344-21-8 4-benzylidene-2... | CAS号42344-23-0 2-(3-methylphen... | CAS号630117-18-9 [(3-methylbenzo...

📜间甲基苯甲酸置于氯化亚砜,Sodium Hydroxide体系中,化学反应 4.5H,反应生成3-甲基马尿酸
参考文献:Synthesis And Quantitative Structure-Activity Relationships Study For Arylpropenamide Derivatives As Inhibitors Of Hepatitis B Virus Replication
标题:Synthesis And Quantitative Structure-Activity Relationships Study For Arylpropenamide Derivatives As Inhibitors Of Hepatitis B Virus Replication
摘要:A Series Of New Arylpropenamide Derivatives Containing Different Aryl Groups Were Synthesized,Characterized,And Evaluated For Their Anti‐hepatitis B Virus (Hbv) Activities. A New High Accuracy Qsar Model Of Arylpropenamide Was Constructed Based On A More Completely Activities Data And Calculation Parameter. The 2D‐qsar Equations,By Using Dft And Multiple Linear Regression Analysis Methods,Revealed That Higher Value Of Thermal Energy (Te) And Lower Entropy (Sө) Increase The Anti‐hbv Activities Of The Arylpropenamide Molecules. Predictive 3D‐qsar Models Were Established By Sybyl Multifit Molecular Alignment Rule. The Optimum Models Were All Statistically Significant With Cross‐validated And Conventional Coefficients,Indicating That They Were Reliable Enough For Activity Prediction.
Doi:10.1111/cbdd.12774

专利信息

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.