CAS: 212333-72-7; 2-(((Dimethylamino)(Dimethyliminio)Methyl)Thio)Pyridine 1-Oxide Hexafluorophosphate(V)
该化合物是一种反应性很强的硫酸盐,主要用作合成和其他有机转化的混合试剂. 其主要优点包括启动氨化物结合的碳oxylic酸,典型反应条件下的稳定性和与多种功能组的兼容性等.六氟磷酸反离子在保持低湿度的杂交性的同时,会增强有机溶剂的溶性. 丙烯基-N-氧化物会进一步提高反应性,使其在挑战混合反应方面特别有用. 这一试剂在以最小的种族化方式生产高产量,使其适合要求合成应用方面具有可靠性,其价值很高.
- 英文名称2-(((Dimethylamino)(Dimethyliminio)Methyl)Thio)Pyridine 1-Oxide Hexafluorophosphate(V)
- 中文名称HOTT N-羟基-5-降冰片烯-2,3-二甲酰亚胺
- IUPAC名称2-((bis(dimethylamino)methylene)sulfonio)pyridine 1-oxide hexafluorophosphate(V)
- 其它别名N,N,N',N'-四甲基-S-(1-氧代-2-吡啶基)硫脲六氟磷酸盐; N-{(Dimethylamino)[(1-Oxidopyridin-2-yl)Sulfanyl]Methylidene}-N-Methylmethanaminium Hexafluorophosphate
- CAS编号212333-72-7
- MFCD编号:MFCD08274618
- EINECS号:805-907-2
- 分子式:C10H16F6N3OPS分子量:371.29
- 产品CID: 1096774
- 产品分类有机原料→通用试剂→缩合反应&活性酯化反应
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报合成工艺路线路线简述
专利信息
专利号:WO-2025088147-A1
优先权日:2023-10-27
标题 :Theranostic psma-targeting ligands for the diagnosis and treatment of psma-expressing cancers and their solid phase synthesis
发明人：Schäfer Martin; BAUDER-WUEST ULRIKE; ROSCHER MAREIKE; REMDE YVONNE; BENEÅ OVÃ?-SCHÄFER MARTINA; BARINKA CYRIL; KUTILOVÃ? ZSÓFIA; MOTLOVÃ? LUCIA
权利人:DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS
摘要:The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and radiopharmaceuticals for the treatment of various disease states of PSMA-expressing cancers, especially prostate cancer, and metastases thereof. Further the present invention provides synthetic procedures for the synthesis of such PSMA-targeting ligands.
专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
专利号:US-10544186-B2
优先权日:2016-11-09
标题:Process for the synthesis of amide bonds with the aid of novel catalysts
发明人：IGNATYEV NIKOLAI MYKOLA; FRANK WALTER; BARTHEN PETER; VYSOTSKY MYROSLAV
权利人:MERCK PATENT GMBH
摘要:The invention relates to a process for the production of amide bonds, in particular peptide bonds, with the aid of novel amide linking reagents containing an anion of the formula (I), to the novel reagents, and to the preparation thereof.
专利号:US-2019270768-A1
优先权日:2016-11-09
标题 :Process for the synthesis of amide bonds with the aid of novel catalysts
专利号:CN-117843715-A
优先权日:2023-12-15
标题 :Liquid phase synthesis method of melanoputan-II
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Process For The Synthesis Of Amide Bonds With The Aid Of Novel Catalysts摘要:The Invention Relates To A Process For The Production Of Amide Bonds, In Particular Peptide Bonds, With The Aid Of Novel Amide Linking Reagents Containing An Anion Of The Formula (I), To The Novel Reagents, And To The Preparation Thereof.
合成参考文献
参考文献:10.1007/bf01901148
摘要:Hansen-Delkeskamp E, Duspiva F. [Course of activity of the enzymatic phosphorylation of thymidine during development of the sea urchin Psammechinus miliaris from fertilization up to the 2-cell stage]. Experientia. 1966 Jun 15;22(6):381–2. doi: 10.1007/bf01901148.
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