CAS: 205110-48-1; Cethromycin

上下游产品

acetic acid 2-[4-(5-acetoxy-4-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-7-allyloxy-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yloxy]-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester 2',4-O-diacetyl-6-O-allyl-11,12-cycl°Carbamate erythromycin A acetic acid 2-(11-allyloxy-4-ethyl-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester acetic acid 2-(11-allyloxy-4-ethyl-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester

📜在 盐酸,甲醇,Ammonium Hydroxide,N-氯代丁二酰亚胺,二甲基硫,Palladium Diacetate,三乙胺,三(邻甲基苯基)磷体系中,用 四氢呋喃,乙醇,二氯甲烷,水,乙腈 用作溶剂,化学反应 312.5H,反应生成喹红霉素
参考文献:抗菌活性を有する6−o−置換ケトリド
标题:抗菌活性を有する6−o−置換ケトリド
摘要:要解决的问题:提供具有抗菌活性的6-O-取代酮烯类化合物,具有酸稳定性,并对革兰氏阴性细菌和大环内酯耐药革兰氏阳性细菌具有增强活性.解决方案:本发明提供6-O-取代红霉素酮烯类衍生物,如式(II)所示,以及包含这些化合物的组合物.[y和z一起形成一个基团x;X是酮基,羟基亚胺基或类似物;或者,Y和z中的一个是h,另一个是氢,羟基或类似物;R是h,羟基;R是h或羟基保护基团;R是取代甲基基团].

专利信息

专利号:US-2023399688-A1
优先权日:2015-08-20
标 题 :Compositions and multiplexed systems for coupled cell-free transcription-translation and protein synthesis and methods for using them
发明人：CULLER STEPHANIE; CHEN IHSIUNG BRANDON; PHARKYA PRITI; VAN DIEN STEVE; BARTON NELSON
权利人:GENOMATICA INC
摘要:In alternative embodiments, provided herein are transcription/translation (TX-TL) systems and methods of using them for use as rapid prototyping platforms for the synthesis, modification and identification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites, from biosynthetic gene cluster pipelines. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the combinatorial biosynthesis of natural products (NPs), natural product analogs (NPAs) and secondary metabolites. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the rapid prototyping of complex biosynthetic pathways as a way to rapidly assess combinatorial and biosynthetic designs before moving to cellular hosts. In alternative embodiments, these exemplary TX-TL systems are multiplexed for high-throughput (HT) automation and for prototyping engineered platforms for the synthesis or modification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites analogs.

专利号:WO-2024007055-A1
优先权日:2022-07-05
标 题 :Method of production of modified phage and method of treatment using same
发明人：WORMALD PETER-JOHN; VREUGDE SARAH SYLVIA JOSEPH; LIU SHA; PSALTIS ALKIVIADIS JAMES; BOURAS GEORGE SPYRO; SHEARWIN KEITH EDWARD
权利人:UNIV ADELAIDE; AUSHEALTH CORP PTY LTD
摘要:A method of producing modified bacteriophage ('phage') that are capable of infecting and causing lysis of a parent host bacteria that is insensitive to the unmodified phage is disclosed. The method comprises: treating a host bacteria insensitive to a selected phage strain with a suitable amount of the said phage strain and at least one antibacterial agent comprising protein synthesis inhibitory activity, and culturing the bacteria for a period and under conditions suitable for the phage to infect the bacteria and replicate to generate progeny phage; and recovering and expanding progeny phage which are phage with a modified capability to infect and cause lysis of said host bacteria. Methods of treatment involving the use of the modified phage, as well as pharmaceutical compositions comprising same are also disclosed.

专利号:US-12421537-B2
优先权日:2018-07-06
标 题:Ribosome variants for sequence defined polymer synthesis
发明人：JEWETT MICHAEL CHRISTOPHER; D'AQUINO ANNE E
权利人:UNIV NORTHWESTERN
摘要:Disclosed are engineered or modified E. coli ribosomes and methods, components, compositions, and kits for preparing and identifying engineered or modified E. coli ribosomes. The engineered or modified E. coli ribosomes may be prepared and identified under a set of defined conditions, such as in the presences of a engineered or modified tRNA comprising a non-natural, non-α-amino acid monomer (NNA), in order to obtain an engineered or modified ribosome that utilizes the engineered or modified tRNA as a substrate for synthesizing a polymer comprising the NNA.

专利号:US-11382882-B2
优先权日:2010-03-08
标 题 :Anti-virulence compositions and methods
发明人：SHOHAM MENACHEM
权利人:UNIV CASE WESTERN RESERVE
摘要:A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.