CAS: 2002-22-4; (αs)-α-Amino-2,3-Dihydro-2-Thioxo-1H-Imidazole-4-Propanoic Acid

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351-50-8 4998-57-6 71-00-1

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CAS号6298-07-3 Ornithine,N2,N5... | CAS号333-20-0 硫氰酸钾 | CAS号71-00-1 L-组氨酸 | CAS号5934-29-2 L-组氨酸盐酸盐,一水 | CAS号4467-54-3 D-组氨酸甲酯二盐酸盐 | CAS号17791-51-4 N(Α), N-(IM)-二-... | CAS号71-00-1 L-组氨酸

📜L-组氨酸盐酸盐置于氢碘酸,溴体系中,化学反应 18.12H,反应生成2-硫代组氨酸
参考文献:Synthesis Of 2-S-Cysteinylhistidine And 2-Mercaptohistidine Via Bromolactone Derivative Of Histidine
标题:Synthesis Of 2-S-Cysteinylhistidine And 2-Mercaptohistidine Via Bromolactone Derivative Of Histidine
摘要:
Doi:10.1021/jo00219A044

专利信息

专利号:US-8835477-B2
优先权日:2009-10-06
标题 :Method for the synthesis of 2-thiohistidine and the like
发明人：ERDELMEIER IRÈNE; DAUNAY SYLVAIN
权利人:ERDELMEIER IRÈNE; DAUNAY SYLVAIN; TETRAHEDRON
摘要:Methods for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60° C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.

专利号:US-10087221-B2
优先权日:2013-03-21
标题 :Synthesis of hydantoin containing peptide products
发明人：HENKEL BERND
权利人:SANOFI AVENTIS DEUTSCHLAND
摘要:The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.

专利号:US-7767826-B2
优先权日:2007-10-05
标题 :Process for the synthesis of L-(+)-ergothioneine
发明人：TRAMPOTA MIROSLAV
权利人:PHARMATECH INTERNATIONAL INC
摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.

专利号:US-5438151-A
优先权日:1993-06-28
标 题 :Process for the preparation of ergothioneine
发明人：YADAN JEAN C Y; XU JINZHU
权利人:BIOXYTECH
摘要:The invention relates to a novel process for the preparation of ergothioneine. n The process for the chemical synthesis of the different optical forms of ergothioneine essentially comprises steps which consist in preparing or using an N.sub.α,N.sub.α -dimethylated histidine ester salt (optically active if necessary), treating this compound with an alkyl, alkenyl or aryl halogenothionoformate in the presence of a base, protecting the sulfur-containing substituent in the compound obtained, converting this protected compound to a compound of the trimethylammonium type and freeing the desired ergothioneine by saponification or acid hydrolysis, as appropriate. n This process affords a better yield and ensures an excellent optical purity.

专利号:US-2009093642-A1
优先权日:2007-10-05
标 题 :Process for the synthesis of l-(+)-ergothioneine

专利号:WO-2011042480-A1
优先权日:2009-10-06
标题 :Method for the synthesis of ergothioneine and the like