CAS: 19230-55-8; 3-Chloro-5-Methylpyridine

相似化合物

329202-22-4 51269-82-0 847610-86-0

3-甲基吡啶-5-硼酸频哪醇酯置于copper Dichloride体系中,用 甲醇 用作溶剂,以204 Mg的收率获得3-氯-5-甲基吡啶
参考文献:通过铱催化的芳烃硼化反应 1,3-二取代芳烃的间位卤化
标题:通过铱催化的芳烃硼化反应 1,3-二取代芳烃的间位卤化
摘要:我们报告了 1,3-二取代芳烃的间位卤化,通过使用铱催化的芳烃硼化化学形成 3,5-二取代芳基溴化物和氯化物.铱催化的芳烃与 B2Pin2 发生硼化反应,然后硼酸酯与溴化铜或氯化铜 (II) 反应,将芳基硼酸酯转化为相应的芳基卤化物.各种含有烷氧基,烷基,卤素,腈,酯,酰胺和新戊酰基的芳烃和 Tips 保护的醇以 46% 到 85% 的收率转化为相应的 3,5-二取代芳基溴化物和氯化物.此外,2,6-二取代和3-取代吡啶分别转化为4-卤代和5-卤代吡啶.
Doi:10.1021/ja076498N

专利信息

专利号:US-8106031-B2
优先权日:2006-05-02
标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-8853410-B2
优先权日:2009-04-30
标 题:Process for preparing substituted isoxazoline compounds and their precursors
发明人：RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN
权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE
摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:WO-2023114200-A2
优先权日:2021-12-14
标题 :Methods for the synthesis of complement factor d inhibitors and intermediates thereof

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.