📜二(三甲基甲硅烷基)乙炔置于一氯化碘体系中,用 四氯化碳 用作溶剂,以90%的收率获得1-碘-2-三甲基硅基乙炔 参考文献:Halogenation Of Alkynes And Alkynylsilanes 标题:Halogenation Of Alkynes And Alkynylsilanes 摘要: Doi:10.1016/0022-328X(89)87090-1
专利号:US-5338865-A 优先权日:1992-03-12 标 题 :Synthesis of halichondrin B and norhalichondrin B 发明人:KISHI YOSHITO; FANG FRANCIS; FORSYTH CRAIG J; SCOLA PAULA M; YOON SUK KYOON 权利人:HARVARD COLLEGE 摘要:Novel chemical compounds that can be used to synthesize halichondrin B and norhalichondrin B, and related derivatives, are described. The synthesis of halichondrin B and norhalichondrin B from these compounds also is described.
专利号:US-7232842-B2 优先权日:2003-01-10 标题:Kinase inhibitors and associated pharmaceutical compositions and methods of use 发明人:WENDER PAUL A; SCANIO MARC J 权利人:UNIV LELAND STANFORD JUNIOR 摘要:The invention provides novel compounds useful as kinase inhibitors or as starting materials And/or intermediates in the synthesis of compounds useful as kinase inhibitors. The compounds have The general structure of formula (I) n nwherein A is a 3- to 8-membered ring, optionally substituted and/or heteroatom-containing, and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, Y, Z, p, and q are as defined herein. The compounds may also be in the form of a salt, ester, amide, or other analog. In preferred compounds, A is a 5- to 8-membered ring, R 1 is hydrogen, q is a bond, X is N, Y is Câ•?O, Z is N, R 2 contains a terminal amino moiety, p is 1, and R 3 and R 4 are linked to form a pyrrole ring fused to a second cyclic group. Pharmaceutical compositions and methods for using the compounds are also provided.
专利号:US-2006223947-A1 优先权日:2005-04-05 标题 :Chemical synthesis of polymeric nanomaterials and carbon nanomaterials 发明人:OLESIK SUSAN V; DING LUNHAN 权利人:UNIV OHIO STATE RES FOUND 摘要:A high yield method for chemically synthesizing low polydispersivity carbon microspheres, nanospheres, nanocrystals, nanotubes, or nanofibers comprising dispersing a self-polymerizing end-capped polyyne in a solvent; heating the dispersed self-polymerizing end-capped tetrayne to form a polymeric material selected from the group consisting of polymer microspheres, polymer nanospheres, polymer nanocrystals, polymer nanotubes, and polymer nanofibers; and pyrolyzing the polymeric material to form a carbon material selected from the group consisting of carbon microspheres, carbon nanospheres, carbon nanocrystals carbon nanotubes, and carbon nanofibers, wherein the polydispersivity is less than 2.
专利号:US-5436238-A 优先权日:1992-03-12 标 题:Halichondrins and related compounds 发明人:KISHI YOSHITO; FANG FRANCIS; FORSYTH CRAIG J; SCOLA PAULA M; YOON SUK KYOON 权利人:HARVARD COLLEGE 摘要:Novel chemical compounds that can be used to synthesize halichondrin B and norhalichondrin B, and related derivatives. The total synthesis of halichondrin B and norhalichondrin B is also disclosed.
[参考文献]: Elodie E Marlier, Et Al. Synthesis And Reactivity Of An Isolable Cobalt(I) Complex Containing A β-Diketiminate-Based Acyclic Tetradentate Ligand. Inorg Chem. 2012 Feb 20;51(4):2079-85.
合成参考文献
摘要:Udmark, J.; Brøndsted Nielsen, M., Science of Synthesis Knowledge Updates, (2014) 3, 360. 摘要:Huy, P.; Czekelius, C., Science of Synthesis Knowledge Updates, (2019) 2, 172.